Yang Liu, Xu Longjin, Li Juan, Wang Huan, Sun Jiahong, Yu Ziqiang, Zhao Xiaoqian, Zhao Min, Xi Bo
Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Centers for Disease Control and Prevention of Shandong Province, Jinan, China.
Front Nutr. 2022 Nov 15;9:1011739. doi: 10.3389/fnut.2022.1011739. eCollection 2022.
Glutamine supplementation has been reported to affect blood pressure (BP). However, its role in the progression of hypertension induced by high salt diet (HSD) has not been elucidated. Male normotensive Wistar rats were exposed to high salt diet and treated with different doses of glutamine supplementation. Rats aged 6 weeks were assigned to five groups: (1) Normal-salt diet (0.3% NaCl, NSD); (2) High-salt diet (8% NaCl, HSD); (3) High-salt + low-dose diet (8% NaCl, 0.5 g of L-glutamine/kg body weight, HSLGD); (4) High-salt + middle-dose diet (8% NaCl, 1.5 g of L-glutamine/kg body weight, HSMGD); and (5) High-salt + high-dose diet (8% NaCl, 2.5 g of L-glutamine/kg body weight, HSHGD). After supplementing different doses of glutamine to male Wistar 6-week-old rats fed with HSD for 7 weeks, we found no difference in body weight among groups. Importantly, we showed that dietary L-glutamine supplementation could prevent the development of hypertension in a dose-dependent manner [dramatically lowering systolic blood pressure (SBP) and slightly reducing diastolic blood pressure (DBP) of hypertensive rats, while the differences of DBP between groups did not reach statistical significance]. Our data further elucidated that dietary glutamine supplementation mildly alleviated the degree of left ventricular hypertrophy, including interventricular septal thickness (IVST) and left ventricular posterior wall thickness (LVPWT) in hypertensive rats. Together, our results offer evidence that the dietary uptake of glutamine may be associated with attenuating the development of high salt-induced hypertension and slightly alleviating the degree of left ventricular hypertrophy in hypertensive rats. Therefore, glutamine supplementation may act as a prospective dietary intervention for the treatment of hypertension.
据报道，补充谷氨酰胺会影响血压（BP）。然而，其在高盐饮食（HSD）诱导的高血压进展中的作用尚未阐明。将雄性血压正常的Wistar大鼠暴露于高盐饮食，并给予不同剂量的谷氨酰胺补充剂进行治疗。将6周龄的大鼠分为五组：（1）正常盐饮食（0.3%氯化钠，NSD）；（2）高盐饮食（8%氯化钠，HSD）；（3）高盐+低剂量饮食（8%氯化钠，0.5克L-谷氨酰胺/千克体重，HSLGD）；（4）高盐+中剂量饮食（8%氯化钠，1.5克L-谷氨酰胺/千克体重，HSMGD）；以及（5）高盐+高剂量饮食（8%氯化钠，2.5克L-谷氨酰胺/千克体重，HSHGD）。在对喂食HSD的6周龄雄性Wistar大鼠补充不同剂量的谷氨酰胺7周后，我们发现各组之间体重没有差异。重要的是，我们发现膳食补充L-谷氨酰胺可以剂量依赖性方式预防高血压的发展[显著降低高血压大鼠的收缩压（SBP）并轻微降低舒张压（DBP），而各组之间DBP的差异未达到统计学显著性]。我们的数据进一步阐明，膳食补充谷氨酰胺可轻度减轻高血压大鼠左心室肥厚的程度，包括室间隔厚度（IVST）和左心室后壁厚度（LVPWT）。总之，我们的结果提供了证据，表明膳食摄入谷氨酰胺可能与减轻高盐诱导的高血压发展以及轻微减轻高血压大鼠左心室肥厚程度有关。因此，补充谷氨酰胺可能作为一种潜在的膳食干预措施用于治疗高血压。
