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布鲁里溃疡与医学地理微生物学

Buruli Ulcer and Medical Geo-Microbiology.

作者信息

Manilal Aseer, Tadesse Dagimawie, Sabu Kuzhunellil Raghavanpillai

机构信息

Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Department of Chemistry, College of Life Sciences, Arba Minch University, Arba Minch, Ethiopia.

出版信息

Infect Drug Resist. 2022 Nov 25;15:6811-6814. doi: 10.2147/IDR.S388005. eCollection 2022.

DOI:10.2147/IDR.S388005
PMID:36458199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9707318/
Abstract

Buruli ulcer is a chronic debilitating infectious disease caused by the pathogen , which can be cured if diagnosed and treated in an early stage. However, advanced cases need antibiotic treatment followed by surgical interventions. In this context, an extremely effective and less expensive treatment modality can be developed by means of an extended topical application of certain selected natural clay minerals, most of the time containing illite-smectite having some iron content. There is a scope for developing the speciality, medical geo-microbiology, which is truly a multidisciplinary one, for finding a cure for the severe and advanced cases of BU.

摘要

布鲁里溃疡是一种由病原体引起的慢性致残性传染病,如果在早期诊断和治疗是可以治愈的。然而,晚期病例需要抗生素治疗,随后进行手术干预。在这种情况下,可以通过长期局部应用某些选定的天然粘土矿物来开发一种极其有效且成本较低的治疗方式,这些粘土矿物大多含有一些铁含量的伊利石-蒙脱石。发展专业的医学地球微生物学有一定空间,这实际上是一个多学科领域,用于寻找治愈布鲁里溃疡严重和晚期病例的方法。

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Buruli Ulcer and Medical Geo-Microbiology.布鲁里溃疡与医学地理微生物学
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Silver Sulfadiazine Eradicates Antibiotic-Tolerant and Biofilms in Patients with Infected Diabetic Foot Ulcers.磺胺嘧啶银可根除感染性糖尿病足溃疡患者体内的抗生素耐受性细菌及生物被膜。
J Clin Med. 2020 Nov 25;9(12):3807. doi: 10.3390/jcm9123807.
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Buruli ulcer: cured by 8 weeks of oral antibiotics?布鲁里溃疡:口服抗生素8周可治愈?
Lancet. 2020 Apr 18;395(10232):1231-1232. doi: 10.1016/S0140-6736(20)30478-5. Epub 2020 Mar 12.
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Global Epidemiology of Buruli Ulcer, 2010-2017, and Analysis of 2014 WHO Programmatic Targets.全球 2010-2017 年布鲁里溃疡流行病学,以及对 2014 年世卫组织规划目标的分析。
Emerg Infect Dis. 2019 Dec;25(12):2183-2190. doi: 10.3201/eid2512.190427.
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Increased Severity and Spread of Mycobacterium ulcerans, Southeastern Australia.澳大利亚东南部溃疡分枝杆菌的严重程度和传播范围增加。
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Magistral Prescription With Silver Nitrate and Peru Balsam in Difficult-to-Heal Diabetic Foot Ulcers.硝酸银与秘鲁香脂复方制剂治疗难愈性糖尿病足溃疡
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The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.大环内酯毒素分枝杆菌内酯通过抑制mTOR促进布鲁里溃疡中Bim依赖性凋亡。
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Montmorillonite-chitosan-silver sulfadiazine nanocomposites for topical treatment of chronic skin lesions: in vitro biocompatibility, antibacterial efficacy and gap closure cell motility properties.蒙脱土-壳聚糖-磺胺嘧啶银纳米复合材料用于慢性皮肤损伤的局部治疗:体外生物相容性、抗菌功效和闭合间隙细胞迁移特性。
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