Popa Gabriela Loredana, Muntean Alexandru Andrei, Popa Mircea Ioan
Department of Microbiology, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Colentina Clinical Hospital, 020125 Bucharest, Romania.
Pathogens. 2023 Aug 27;12(9):1088. doi: 10.3390/pathogens12091088.
Buruli ulcer (BU) is a bacterial skin infection that is caused by and mainly affects people who reside in the rural areas of Africa and in suburban and beach resort communities in Australia. The infection typically begins as a painless papule or nodule that gradually develops into a large ulcer that can cause substantial impairment, damaging soft tissues and even bones. Early detection and immediate treatment are crucial to preventing further tissue damage and any potential complications, although it is worth noting that access to proper therapeutic resources can be limited in certain areas. The most commonly used antibiotics for treating BU are rifampicin, streptomycin, and clarithromycin; efforts have recently been made to introduce new treatments that increase the effectiveness and adherence to therapy. This article presents the latest research and management strategies regarding BU, providing an updated and intriguing perspective on this topic.
布鲁里溃疡是一种由细菌引起的皮肤感染，主要影响居住在非洲农村地区以及澳大利亚郊区和海滩度假社区的人群。感染通常始于无痛丘疹或结节，随后逐渐发展成大溃疡，可导致严重损伤，损害软组织甚至骨骼。早期发现和立即治疗对于防止进一步的组织损伤和任何潜在并发症至关重要，不过值得注意的是，在某些地区，获得适当治疗资源的机会可能有限。治疗布鲁里溃疡最常用的抗生素是利福平、链霉素和克拉霉素；最近已努力引入能提高治疗效果和依从性的新疗法。本文介绍了有关布鲁里溃疡的最新研究和管理策略，提供了关于该主题的最新且引人入胜的观点。
