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评估心力衰竭住院患者治疗过程中的启发式偏差:Get With The Guidelines-Heart Failure。

Assessing Heuristic Bias During Care for Patients Hospitalized for Heart Failure: Get With The Guidelines-Heart Failure.

机构信息

Division of Cardiology, Duke University School of Medicine, Durham, NC (S.S.).

Duke Molecular Physiology Institute, Durham, NC (S.S.).

出版信息

Circ Heart Fail. 2023 Feb;16(2):e010069. doi: 10.1161/CIRCHEARTFAILURE.122.010069. Epub 2022 Dec 2.

DOI:10.1161/CIRCHEARTFAILURE.122.010069
PMID:36458538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9974743/
Abstract

BACKGROUND

Heuristic biases are increasingly recognized, and potentially modifiable, contributors to patient care and outcomes. Left digit bias is a cognitive bias where continuous variables are categorized by their left-most digit. The impact of this heuristic bias applied to patient age on quality of care in heart failure has not been explored.

METHODS

We examined participants admitted from 2005 to 2021 in the Get With The Guidelines-Heart Failure registry. To create 2 naturally randomized groups, isolating the effect of left digit bias, we dichotomized patients into those discharged within 60 days prior to their 80th birthday (N=4238) and those discharged within 60 days after their 80th birthday (N=4329). We performed multivariable logistic regression to assess the association between discharge date relative to 80th birthday and several in-hospital quality metrics and in-hospital outcomes. Among Medicare participants (N=2759), we performed adjusted Cox regression to analyze the relationship between discharge date and risk of 1-year mortality or readmission.

RESULTS

Among 8567 patients, 50.4% were female, 73% were non-Hispanic White, and 42.9% had an ejection fraction ≤40%. Discharge date relative to 80th birthday was not associated with numerous in-hospital quality metrics or in-hospital outcomes on unadjusted or adjusted logistic regression. Among Medicare beneficiaries, there was no association between discharge date and risk of mortality or readmission at 1-year postdischarge (hazard ratio, 1.03 [95% CI, 0.95-1.12]; =0.52).

CONCLUSIONS

In a large registry of patients hospitalized for heart failure, we did not detect a left digit bias' with respect to age at discharge, which resulted in differential quality of care or outcomes.

摘要

背景

启发式偏差越来越被认为是影响患者护理和结局的、潜在可改变的因素。左位数偏差是一种认知偏差,其中连续变量根据其最左边的数字进行分类。这种启发式偏差应用于患者年龄对心力衰竭患者护理质量的影响尚未得到探讨。

方法

我们研究了 2005 年至 2021 年在 Get With The Guidelines-Heart Failure 注册中心住院的患者。为了创建 2 个自然随机组,以隔离左位数偏差的影响,我们将患者分为在 80 岁生日前 60 天内出院的(N=4238)和在 80 岁生日后 60 天内出院的(N=4329)。我们进行多变量逻辑回归分析,以评估出院日期与多项院内质量指标和院内结局之间的关系。在 Medicare 参与者中(N=2759),我们进行了调整后的 Cox 回归分析,以分析出院日期与 1 年死亡率或再入院风险之间的关系。

结果

在 8567 名患者中,50.4%为女性,73%为非西班牙裔白人,42.9%的射血分数≤40%。在未经调整或调整后的逻辑回归中,出院日期与许多院内质量指标或院内结局均无关联。在 Medicare 受益人中,出院日期与 1 年后的死亡率或再入院风险之间没有关联(危险比,1.03[95%CI,0.95-1.12];P=0.52)。

结论

在一项大型心力衰竭住院患者注册研究中,我们没有发现与出院时年龄相关的左位数偏差,这导致了护理质量或结局的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e762/9974743/8f64e5e7aee0/nihms-1846978-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e762/9974743/93536ce3cf3c/nihms-1846978-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e762/9974743/6714f90e2d6b/nihms-1846978-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e762/9974743/8f64e5e7aee0/nihms-1846978-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e762/9974743/93536ce3cf3c/nihms-1846978-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e762/9974743/6714f90e2d6b/nihms-1846978-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e762/9974743/8f64e5e7aee0/nihms-1846978-f0003.jpg

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本文引用的文献

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Electronic Alerts to Improve Heart Failure Therapy in Outpatient Practice: A Cluster Randomized Trial.电子提醒改善门诊心力衰竭治疗:一项集群随机试验。
J Am Coll Cardiol. 2022 Jun 7;79(22):2203-2213. doi: 10.1016/j.jacc.2022.03.338. Epub 2022 Apr 3.
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Baseline Characteristics of Patients With HF With Mildly Reduced and Preserved Ejection Fraction: DELIVER Trial.射血分数轻度降低和保留的心力衰竭患者的基线特征:DELIVER试验
JACC Heart Fail. 2022 Mar;10(3):184-197. doi: 10.1016/j.jchf.2021.11.006.
3
Regional Variations in Heart Failure Quality and Outcomes: Get With The Guidelines-Heart Failure Registry.
心力衰竭质量和结局的区域差异:遵循指南-心力衰竭注册研究。
J Am Heart Assoc. 2021 Apr 6;10(7):e018696. doi: 10.1161/JAHA.120.018696. Epub 2021 Mar 24.
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Behavioral Heuristics in Coronary-Artery Bypass Graft Surgery.冠状动脉搭桥手术中的行为启发式方法
N Engl J Med. 2020 Feb 20;382(8):778-779. doi: 10.1056/NEJMc1911289.
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Guideline-directed medical therapy in elderly patients with heart failure with reduced ejection fraction: a cohort study.指导下的医学治疗在老年射血分数降低心力衰竭患者中的应用:一项队列研究。
BMJ Open. 2020 Feb 6;10(2):e030514. doi: 10.1136/bmjopen-2019-030514.
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Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.达格列净治疗射血分数降低的心力衰竭患者。
N Engl J Med. 2019 Nov 21;381(21):1995-2008. doi: 10.1056/NEJMoa1911303. Epub 2019 Sep 19.
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The Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial: baseline characteristics.达格列净和心力衰竭结局预防(DAPA-HF)试验:基线特征。
Eur J Heart Fail. 2019 Nov;21(11):1402-1411. doi: 10.1002/ejhf.1548. Epub 2019 Jul 15.
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Titration of Medical Therapy for Heart Failure With Reduced Ejection Fraction.射血分数降低的心力衰竭的药物治疗滴定。
J Am Coll Cardiol. 2019 May 21;73(19):2365-2383. doi: 10.1016/j.jacc.2019.02.015. Epub 2019 Mar 4.
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J Am Coll Cardiol. 2018 Jul 24;72(4):351-366. doi: 10.1016/j.jacc.2018.04.070.
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J Am Heart Assoc. 2018 Mar 30;7(7):e008158. doi: 10.1161/JAHA.117.008158.