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药剂师主导的糖尿病周围神经病变筛查,使用密歇根神经病变筛查工具(MNSI)。

Pharmacist-lead screening for diabetic peripheral neuropathy using Michigan Neuropathy Screening Instrument (MNSI).

机构信息

Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.

出版信息

Int J Neurosci. 2024 Aug;134(8):882-888. doi: 10.1080/00207454.2022.2154671. Epub 2022 Dec 19.

Abstract

BACKGROUND

Diabetic peripheral neuropathy (DPN) is highly prevalent among Jordanian patients, mostly are asymptomatic. Early recognition and appropriate management of neuropathy is important to improve symptoms, reduce sequelae, and improve quality of life. This study aims at exploring the role of pharmacists in the early recognition of DPN and providing quick screening for the presence of it among diabetic patients.

MATERIAL AND METHODS

A cross-sectional study was conducted at multi-pharmacy settings, in Irbid, Jordan. Twenty trained pharmacists who had bachelor's degrees in pharmacy participated in data collection. A total of 400 patients with confirmed diagnosis of type 2 diabetes mellitus (DM) according to the World Health Organization diagnostic criteria were recruited. DPN was assessed using the translated Arabic version of Michigan Neuropathy Screening Instrument (MNSI) history version.

RESULTS

The mean MNSI questionnaire score for all participants was 4.40 ± 3.00. Mean age of the patients was 62.6 ± 10.7 years old and duration of diabetes was 8.25 ± 6.9. DN was present in 23.7% of the population. Diabetic patients with neuropathy were older than patients without neuropathy ( < 0.05) and had had diabetes longer ( < 0.05). Poor glycemic control, hypertension and gender, were significantly risk factors for DN ( < 0.05).

CONCLUSIONS

In addition to delivering medications, this study suggests that pharmacists can have a role in screening and counseling about diabetic peripheral neuropathy using a simple objective, and non-invasive tool and also can determine level of damage and risk.

摘要

背景

糖尿病周围神经病变(DPN)在约旦患者中患病率很高,大多数患者无症状。早期识别和适当的神经病变管理对于改善症状、减少后遗症和提高生活质量非常重要。本研究旨在探讨药剂师在早期识别 DPN 中的作用,并为糖尿病患者提供快速筛查其神经病变的方法。

材料和方法

在约旦伊尔比德的多药房环境中进行了一项横断面研究。20 名具有药学学士学位的经过培训的药剂师参与了数据收集。共招募了 400 名根据世界卫生组织诊断标准确诊为 2 型糖尿病(DM)的患者。使用经过翻译的阿拉伯语版密歇根神经病变筛查工具(MNSI)病史版本评估 DPN。

结果

所有参与者的 MNSI 问卷平均得分为 4.40±3.00。患者的平均年龄为 62.6±10.7 岁,糖尿病病程为 8.25±6.9 年。DN 的患病率为 23.7%。患有神经病变的糖尿病患者比没有神经病变的患者年龄更大(<0.05),且糖尿病病程更长(<0.05)。血糖控制不佳、高血压和性别是 DN 的显著危险因素(<0.05)。

结论

除了提供药物治疗外,本研究还表明,药剂师可以使用简单的客观、非侵入性工具进行糖尿病周围神经病变的筛查和咨询,还可以确定损伤程度和风险。

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