Vandeweege Sander, Debaene Britt, Lapeere Hilde, Verstraelen Hans
Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
Contact Dermatitis. 2023 Apr;88(4):249-262. doi: 10.1111/cod.14258. Epub 2022 Dec 13.
Vulvar allergic contact dermatitis (vACD) and irritant contact dermatitis (vICD) are common and accompanied by a great burden on the patient's life. We aimed to review the existing literature on vACD and vICD in order to provide a comprehensive reference list of potential vulvar allergens and irritants, as well as to establish the role of patch testing therein. A systematic search was performed in Medline, Embase and Web of Science using a search string based on the PICO-format. The study protocol was registered at PROSPERO (CRD42021239527). Multiple allergens were identified and included metals, topical drugs, fragrances, preservatives, cosmetic constituents and rubber components. Not all positive reactions were, however, considered to be relevant. Patch testing is the primary tool for the identification of the causal allergens. Testing with standard series alone was proven to be insufficient. Little information about irritants was found. In the future, additional series and late readings should be considered in standard practice. Studies on vICD are scarce and further research is necessary. More population-based research should be performed.
外阴过敏性接触性皮炎（vACD）和刺激性接触性皮炎（vICD）很常见，给患者的生活带来极大负担。我们旨在回顾关于vACD和vICD的现有文献，以便提供一份潜在外阴过敏原和刺激物的综合参考清单，并确定斑贴试验在其中的作用。使用基于PICO格式的检索词在Medline、Embase和科学网进行了系统检索。该研究方案已在国际前瞻性系统评价注册库（PROSPERO，注册号：CRD42021239527）登记。已确定多种过敏原，包括金属、外用药物、香料、防腐剂、化妆品成分和橡胶成分。然而，并非所有阳性反应都被认为具有相关性。斑贴试验是识别致病过敏原的主要工具。事实证明，仅使用标准系列进行测试是不够的。关于刺激物的信息很少。未来，在标准实践中应考虑增加系列试验和延迟读数。关于vICD的研究很少，有必要进一步开展研究。应开展更多基于人群的研究。
