School of Medicine, University of Utah, Salt Lake City, UT, USA.
Department of Dermatology, University of Utah, 30 North 1900 East, 4A330, Salt Lake City, UT, 84132, USA.
Arch Dermatol Res. 2023 Jul;315(5):1109-1128. doi: 10.1007/s00403-022-02487-0. Epub 2022 Dec 2.
Solid organ and stem cell transplants are increasingly common, and dermatologists will more frequently encounter and need to manage common skin diseases, such as psoriasis, in transplant patients. This review explores psoriasis remission and occurrence in recipients of solid organ and stem cell transplants. Hematopoietic and mesenchymal stem cell transplants may show potential for treating psoriasis in patients with leukemia or who have other medical conditions requiring stem cell transplant. The effects of solid organ transplant are less clear, partly due to limitations in the breadth of the literature. De novo psoriasis has been reported in recipients of solid organ transplants, but the reasons for this development have yet to be fully understood. Overall, the literature on this subject is limited to primarily case reports. Feasibility of studies on the subject may be a considerable barrier to further research assessing the use of transplant for treating psoriasis, but there is potential benefit from transplant for psoriasis patients. This subject should receive further exploration to fully understand these benefits.
实体器官和干细胞移植越来越普遍，皮肤科医生将更频繁地遇到并需要管理移植患者的常见皮肤病，如银屑病。这篇综述探讨了实体器官和干细胞移植受者的银屑病缓解和发生情况。造血和间充质干细胞移植可能为白血病患者或有其他需要干细胞移植的医疗条件的患者提供治疗银屑病的潜力。实体器官移植的效果不太明确，部分原因是文献的广度有限。已报道在实体器官移植受者中出现新发银屑病，但尚未完全了解其发病原因。总体而言，关于该主题的文献主要限于病例报告。该主题的研究可行性可能是进一步研究评估移植治疗银屑病的使用的一个相当大的障碍，但移植对银屑病患者有潜在的益处。这个主题应该得到进一步的探索，以充分了解这些益处。
