衰老与免疫衰老的相互作用：衰老的新治疗靶点。

Interaction of aging and Immunosenescence: New therapeutic targets of aging.

机构信息

Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, and Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China; Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China.

Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China.

出版信息

Int Immunopharmacol. 2022 Dec;113(Pt A):109397. doi: 10.1016/j.intimp.2022.109397. Epub 2022 Nov 3.

DOI:10.1016/j.intimp.2022.109397

PMID:36461596

Abstract

Aging is a natural physiological process, but aging can increase the prevalence and mortality of chronic diseases in the elderly. It involves multiple organs and systems, and an essential aspect of aging is immunosenescence. With the increase of age, the immune system has undergone a series of changes and disorders. These changes have led to a decline in the resistance of the elderly to infection, reduced immunity to vaccines, increased incidence of cancer and autoimmune diseases, and an increased structural prevalence of low-grade inflammation. Moreover, affecting the aging process to a certain extent. This review introduces the changes in the immune system during aging and discusses the consequences and effects of these changes. And its effect on the aging process and the methods and ways of anti-aging were discussed.

摘要

衰老是一种自然的生理过程，但衰老会增加老年人慢性病的患病率和死亡率。它涉及多个器官和系统，衰老是免疫衰老的一个重要方面。随着年龄的增长，免疫系统经历了一系列的变化和紊乱。这些变化导致老年人对感染的抵抗力下降，对疫苗的免疫力降低，癌症和自身免疫性疾病的发病率增加，以及低水平炎症的结构性流行率增加。此外，在一定程度上影响衰老过程。本综述介绍了衰老过程中免疫系统的变化，并讨论了这些变化的后果和影响。及其对衰老过程的影响以及抗衰老的方法和途径。