Universidade da Coruña, Gerontology and Geriatrics Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS), A Coruña, Spain.
Universidade da Coruña, Grupo NanoToxGen, CICA - Centro Interdisciplinar de Química e Bioloxía, Departamento de Biología, A Coruña, Spain; Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain; Universidade da Coruña, Grupo DICOMOSA, CICA - Centro Interdisciplinar de Química e Bioloxía, Departamento de Psicología, A Coruña, Spain.
Mutat Res Genet Toxicol Environ Mutagen. 2022 Nov-Dec;883-884:503557. doi: 10.1016/j.mrgentox.2022.503557. Epub 2022 Oct 7.
Recent studies exploring the relationship between DNA damage measured by the comet assay (single-cell gel electrophoresis) and cognitive function in both animal models and humans are reviewed and summarized. This manuscript provides an overview of studies exploring cognitive dysfunction related to DNA damage due to biological ageing process, cancer treatment, adverse environmental or occupational exposures, and prenatal genotoxic exposure. The review confirms the potential of comet assay to further explore the link between DNA damage, as indicative of genomic instability, and cognitive impairment in different research and clinical areas. Analysed studies support, in fact, the significant relationship between DNA damage and cognitive impairment, mainly affecting attention, working memory and executive functions. These cognitive domains are crucial to daily functioning and occupational performance, with important clinical implications. Although evidence support the relationship between DNA damage measured by the comet assay and cognitive function in different settings, further longitudinal research is needed to disentangle the temporal relationship between them over time, and to explore the potential of comet assay-detected DNA lesions to predict response to interventions.
最近的研究探索了彗星试验（单细胞凝胶电泳）测量的 DNA 损伤与动物模型和人类认知功能之间的关系，并对这些研究进行了综述和总结。本文概述了探索由于生物老化过程、癌症治疗、不利的环境或职业暴露以及产前遗传毒性暴露导致的 DNA 损伤与认知功能障碍之间关系的研究。综述证实了彗星试验在不同研究和临床领域进一步探索 DNA 损伤（作为基因组不稳定性的指标）与认知障碍之间联系的潜力。分析的研究实际上支持 DNA 损伤与认知障碍之间的显著关系，主要影响注意力、工作记忆和执行功能。这些认知领域对日常功能和职业表现至关重要，具有重要的临床意义。尽管有证据支持彗星试验测量的 DNA 损伤与不同环境下的认知功能之间的关系，但仍需要进一步的纵向研究来阐明它们之间随时间的时间关系，并探索彗星试验检测到的 DNA 损伤预测对干预措施的反应的潜力。
