Gerić Marko, Pehnec Gordana, Matković Katarina, Rinkovec Jasmina, Jakovljević Ivana, Godec Ranka, Žužul Silva, Bešlić Ivan, Cvitković Ante, Delić Luka, Wild Pascal, Guseva Canu Irina, Hopf Nancy B, Gajski Goran
Division of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.
Division of Environmental Hygiene, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.
J Xenobiot. 2024 Mar 13;14(1):368-379. doi: 10.3390/jox14010023.
More than eight million premature deaths annually can be attributed to air pollution, with 99% of the world's population residing in areas below recommended air quality standards. Hence, the present study aimed to examine the association between primary DNA damage and air pollution data among 123 participants enrolled between 2011 and 2015 in Zagreb, Croatia. While most measured air pollutants adhered to regulatory limits, benzo[a]pyrene concentrations bound to PM exceeded them. Factorial analysis narrowed down air pollution data to four exposure factors (particulate matter, two metal factors, and other pollutants). Despite the absence of significant positive associations between modeled air pollution exposure factors and comet assay descriptors (tail length, tail intensity, tail moment, and highly damaged nuclei), the critical health implications of air pollution warrant further investigations, particularly with biomarkers of exposure and different biomarkers of effect in populations facing air pollution exposure.
每年有超过800万人过早死亡可归因于空气污染，全球99%的人口居住在空气质量低于推荐标准的地区。因此，本研究旨在调查2011年至2015年间在克罗地亚萨格勒布招募的123名参与者中，原发性DNA损伤与空气污染数据之间的关联。虽然大多数测量的空气污染物符合监管限值，但与颗粒物结合的苯并[a]芘浓度超过了限值。因子分析将空气污染数据缩小到四个暴露因素（颗粒物、两种金属因素和其他污染物）。尽管模拟的空气污染暴露因素与彗星试验描述指标（尾长、尾强度、尾矩和高度受损细胞核）之间没有显著的正相关，但空气污染对健康的严重影响值得进一步研究，特别是在面临空气污染暴露的人群中使用暴露生物标志物和不同的效应生物标志物进行研究。
