Karamitsou Paraskevi, Skliris James Philip, Karamitsou Aikaterini, Forozidou Evropi, Poutoglidis Alexandros
Otorhinolaryngology, 'G. Papanikolaou' General Hospital, Thessaloniki, GRC.
Pathology, 'G. Papanikolaou' General Hospital, Thessaloniki, GRC.
Cureus. 2022 Oct 31;14(10):e30901. doi: 10.7759/cureus.30901. eCollection 2022 Oct.
Liposarcomas are rare mesenchymal tissue tumors and are divided into subtypes based on their histopathological characteristics. They are mostly well-differentiated neoplasms with the tendency to recur locally. Lymph node involvement or distant metastases have been reported as extremely rare. Common manifestations are progressive dyspnea, dysphagia, choking, and stridor. Surgical excision of laryngeal liposarcomas is considered the gold standard treatment modality for disease eradication. In persistent or recurrent cases, a total laryngectomy should be performed. There is much controversy regarding the role of radiotherapy which is mostly used as adjuvant treatment in specific cases. We present a case of dedifferentiated laryngeal liposarcoma with multiple recurrences and metachronous transformation to a neoplasm with myxofibrosarcomatous elements.
脂肪肉瘤是罕见的间叶组织肿瘤，根据其组织病理学特征可分为不同亚型。它们大多是分化良好的肿瘤，有局部复发的倾向。据报道，淋巴结受累或远处转移极为罕见。常见表现为进行性呼吸困难、吞咽困难、呛咳和喘鸣。手术切除喉脂肪肉瘤被认为是根除该疾病的金标准治疗方式。对于持续性或复发性病例，应行全喉切除术。关于放疗的作用存在诸多争议，放疗大多在特定病例中用作辅助治疗。我们报告一例去分化型喉脂肪肉瘤，该病例多次复发并异时性转变为具有黏液纤维肉瘤成分的肿瘤。
