Tabatabaei-Malazy Ozra, Lavari Narges, Abdollahi Mohammad
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Handb Exp Pharmacol. 2025;287:123-157. doi: 10.1007/164_2024_711.
Metabolic syndrome (MetS) is a prevalent health condition that requires significant attention and intervention due to its multifaceted nature. It encompasses a variety of ailments such as diabetes mellitus, hypertension, obesity, and dyslipidemia. Despite extensive research, the underlying pathophysiology of MetS is not entirely understood, and current synthetic drugs used to treat it have adverse effects and can be expensive. Therefore, natural products are being investigated as a potential alternative treatment for MetS. This chapter provides an overview of studies on natural products as a treatment for MetS. The available evidence suggests that bioactive phytochemicals and herbal medicines, such as curcumin, resveratrol, Nigella sativa, Hibiscus sabdariffa, and Theobroma cacao, have the potential to treat MetS effectively. Furthermore, natural products can be explored as a novel drug discovery approach for MetS. However, it is imperative to conduct well-designed randomized controlled trials with large sample sizes to confirm these findings. Based on our review, we conclude that natural products could be a promising alternative for treating MetS. Further research is warranted to explore this potential fully. The use of natural products for MetS treatment could reduce the reliance on synthetic drugs, many of which have harmful side effects and are costly. The development of natural products as a treatment for MetS could have significant implications for public health, and we encourage further research in this area.
代谢综合征（MetS）是一种普遍存在的健康状况，由于其多方面的性质，需要引起高度关注并进行干预。它包括多种疾病，如糖尿病、高血压、肥胖症和血脂异常。尽管进行了广泛的研究，但MetS的潜在病理生理学尚未完全了解，目前用于治疗它的合成药物有副作用且可能昂贵。因此，天然产物正被作为MetS的一种潜在替代治疗方法进行研究。本章概述了关于天然产物治疗MetS的研究。现有证据表明，生物活性植物化学物质和草药，如姜黄素、白藜芦醇、黑种草、玫瑰茄和可可，有可能有效治疗MetS。此外，天然产物可作为一种针对MetS的新型药物发现方法进行探索。然而，必须进行设计良好、样本量较大的随机对照试验来证实这些发现。基于我们的综述，我们得出结论，天然产物可能是治疗MetS的一种有前景的替代方法。有必要进行进一步研究以充分探索这种潜力。使用天然产物治疗MetS可以减少对合成药物的依赖，其中许多药物有有害副作用且成本高昂。将天然产物开发为MetS的治疗方法可能对公共卫生有重大影响，我们鼓励在这一领域进行进一步研究。
