Department of Engineering Materials and Biomaterials, Faculty of Mechanical Engineering, Silesian University of Technology, Konarskiego 18a, 44-100, Gliwice, Poland.
Department of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Ostrogórska 30, 41-200, Sosnowiec, Poland.
Sci Rep. 2022 Dec 5;12(1):21007. doi: 10.1038/s41598-022-25069-6.
Calcium-based alloys can be promising candidates for use as biodegradable implants because of attractive properties as mechanical, corrosive, and biocompatible. In the work, the biocompatibility authors discussed the results of the CaMgZnYbB (x = 0, 1, 2, 3 at.%) and CaMgZnYbBAu (x = 1, 2 at.%) alloys. The tests were performed using a MTT assay. The corrosion behavior of such Ca-based alloys in PWE fluid at 37 °C was studied and compared with the results in Ringer's solution from previous works. Electrochemical tests were presented by open circuit potential and potentiodynamic curves. Different concentrations of boron and gold in the alloys caused changes in the corrosion results. The best corrosion resistance in PWE solution was observed for the Ca-based alloy with 2 at.% Au due to the lowest value of the corrosion current density (j), equal to 10.6 µA·cm. A slightly higher value of j was obtained for the CaMgZnYbB alloy with the lowest roughness values. The results of the cytotoxicity tests also showed that the alloy with 3 at.% boron was characterized by the highest cell viability. The investigation results discussed in the work allow us to suggest that the presented calcium alloys with 3 at.% of B, and 2 at.% of Au addition may be promising materials for the use in implantology.
基于钙的合金因其具有良好的机械性能、腐蚀性和生物相容性，因此可以作为可生物降解植入物的有前途的候选材料。在这项工作中，作者讨论了 CaMgZnYbB（x = 0、1、2、3 原子%）和 CaMgZnYbBAu（x = 1、2 原子%）合金的生物相容性结果。测试是使用 MTT 测定法进行的。研究了此类钙基合金在 37°C 的 PWE 流体中的腐蚀行为，并与以前工作中 Ringer 溶液的结果进行了比较。电化学测试通过开路电位和动电位曲线进行了呈现。合金中硼和金的不同浓度导致腐蚀结果发生变化。在 PWE 溶液中，具有 2 原子%金的基于钙的合金表现出最佳的耐腐蚀性，因为其腐蚀电流密度（j）值最低，等于 10.6 µA·cm。具有最低粗糙度值的 CaMgZnYbB 合金获得了稍高的 j 值。细胞毒性测试的结果还表明，硼含量为 3 原子%的合金的细胞活力最高。这项工作中讨论的研究结果表明，添加 3 原子%硼和 2 原子%金的所提出的钙合金可能是植入物应用的有前途的材料。
