不要在扑热息痛过量时更自由地使用非那西丁。
Fomepizole should not be used more liberally in paracetamol overdose.
机构信息
Pharmacology, Therapeutics and Toxicology, Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
出版信息
Br J Clin Pharmacol. 2023 Feb;89(2):599-601. doi: 10.1111/bcp.15596. Epub 2022 Dec 5.
Abstract
Fomepizole is a promising new treatment for preventing liver injury following paracetamol (acetaminophen) overdose. However, we need robust clinical trials to be performed to demonstrate its effect on clinical outcomes that are important to our patients and important to healthcare providers. Until such trials are performed, the toxicology community should learn the lessons from the COVID pandemic-potential novel therapeutic options may be theoretically appealing, but their effectiveness needs to be assessed in robust clinical trials before they are used in clinical practice.
摘要
非那西丁是一种有前途的新治疗方法，可预防扑热息痛（对乙酰氨基酚）过量引起的肝损伤。然而，我们需要进行强有力的临床试验，以证明其对我们的患者和医疗保健提供者都很重要的临床结果的影响。在进行这些试验之前，毒理学界应该从 COVID 大流行中吸取教训——潜在的新型治疗选择在理论上可能具有吸引力，但在将它们用于临床实践之前，需要在强有力的临床试验中评估其有效性。
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