Rodrigues Kyle, Hussain Rawdat, Cooke Sarah, Zhang Gary, Zhang Deqiang, Yin Lei, Tong Xin
Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
Caswell Diabetes Institute, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
Metab Target Organ Damage. 2023;3(4). doi: 10.20517/mtod.2023.28. Epub 2023 Oct 29.
Acetaminophen (APAP) is the most widely used analgesic in the world. APAP overdose can cause severe hepatotoxicity and therefore is the most common cause of drug-induced liver injury. The only approved treatment for APAP overdose is N-acetyl-cysteine (NAC) supplementation. However, the narrow efficacy window of the drug severely limits its clinical use, prompting the search for other therapeutic options to counteract APAP toxicity. Recent research has pointed to fructose as a novel nutraceutical for APAP-induced liver injury. This review summarizes the current understanding of the molecular mechanisms underlying APAP-induced liver injury, introduces how fructose supplementation could prevent and treat APAP liver toxicity with a focus on the ChREBPα-FGF21 pathway, and proposes possible future directions of study.
对乙酰氨基酚（APAP）是世界上使用最广泛的镇痛药。APAP过量可导致严重的肝毒性，因此是药物性肝损伤最常见的原因。APAP过量唯一获批的治疗方法是补充N-乙酰半胱氨酸（NAC）。然而，该药物狭窄的疗效窗口严重限制了其临床应用，促使人们寻找其他治疗方法来对抗APAP毒性。最近的研究指出果糖是一种用于治疗APAP诱导的肝损伤的新型营养保健品。本综述总结了目前对APAP诱导肝损伤潜在分子机制的理解，介绍了补充果糖如何预防和治疗APAP肝毒性，重点关注ChREBPα-FGF21途径，并提出了未来可能的研究方向。
