Ma Xiao-Jing, Yang Jian, Ma Gui-Rong, Zeng Wen, Guo Juan, Ma Ying
State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2022 Oct;47(19):5131-5139. doi: 10.19540/j.cnki.cjcmm.20220808.101.
Modernization of Chinese medicine is an important development direction of traditional Chinese medical sciences. It is of great significance to understand the mechanism of Chinese medicine with basic research, which can also accelerate the development and utilization of Chinese medicine. Salviae Miltiorrhizae Radix et Rhizoma is one of the most commonly used Chinese medicines in China for the prevention and treatment of cardiovascular and cerebrovascular diseases. It has received key and extensive attention worldwide in the following aspects: main active ingredients and their pharmacological mechanism, function and regulation of their biosynthetic pathway and application of their synthetic biology as well as the clinical preparations. The new and developing chemical analysis, network pharmacology, molecular pharmacognosy and omics make the modernization research of Salviae Miltiorrhizae Radix et Rhizoma comprehensive and in-depth. This study systematically reviewed the modernization research of Salviae Miltiorrhizae Radix et Rhizoma, which focused on its pharmacological effects, preparation research, biosynthesis and regulation mechanism of the active ingredients, and expected to exert the model role of Salviae Miltiorrhizae Radix et Rhizoma in the research of Chinese medicine.
中药现代化是中医药科学的重要发展方向。运用基础研究来认识中药作用机制具有重要意义，这也能够加速中药的开发与利用。丹参是我国防治心脑血管疾病最常用的中药之一。它在以下几个方面受到了全球的重点和广泛关注：主要活性成分及其药理机制、其生物合成途径的功能与调控、合成生物学的应用以及临床制剂。新兴的化学分析、网络药理学、分子生药学和组学使丹参的现代化研究全面且深入。本研究系统综述了丹参的现代化研究，重点关注其药理作用、制剂研究、活性成分的生物合成及调控机制，期望发挥丹参在中药研究中的示范作用。
