左乙拉西坦治疗对心电图参数的影响。

Effect of levetiracetam therapy on electrocardiographic parameters.

作者信息

Aydin Hilal, Korkut Oğuzhan

机构信息

Department of Pediatrics, Balikesir University, Faculty of Medicine, 10145 Balikesir, Turkey.

Department of Medical Pharmacology, Faculty of Medicine, Balikesir University, 10145 Balikesir, Turkey.

出版信息

Arch Pediatr. 2023 Apr;30(3):149-152. doi: 10.1016/j.arcped.2022.11.002. Epub 2022 Dec 5.

DOI:10.1016/j.arcped.2022.11.002

PMID:36473752

Abstract

AIM

The purpose of this study was to compare the electrocardiographic parameters before and at the sixth month of treatment of patients diagnosed with epilepsy and who were started on levetiracetam therapy.

METHODS

The files of 30 patients diagnosed with epilepsy and on levetiracetam therapy were examined in this study. Clinical findings, electroencephalography (EEG), cranial magnetic resonance imaging (MRI) and electrocardiography (ECG) data before and at the sixth month of treatment were recorded.

RESULTS

The patients' mean age was 10.93 ± 3.74 (4-17) years; 16 (53.33%) patients were boys. In total, 13 (43.3%) were found to experience focal seizures, and 17 (56.7%) generalized epilepsy-type seizures. Comparison of the ECG parameters (PR interval, QTc, QT interval, and QRS duration) revealed a shortening in the PR interval and QTc values at the sixth month of treatment, although the changes were not statistically significant. No significant differences in terms of gender and epilepsy types were observed between the ECG parameters before treatment and at the sixth month (p > 0.05).

CONCLUSION

In this study, levetiracetam was found to have no effect on ECG parameters.

摘要

目的

本研究旨在比较诊断为癫痫并开始接受左乙拉西坦治疗的患者在治疗前及治疗六个月时的心电图参数。

方法

本研究检查了30例诊断为癫痫并接受左乙拉西坦治疗的患者的病历。记录治疗前及治疗六个月时的临床检查结果、脑电图（EEG）、头颅磁共振成像（MRI）及心电图（ECG）数据。

结果

患者的平均年龄为10.93 ± 3.74（4 - 17）岁；16例（53.33%）为男性。总共发现13例（43.3%）经历局灶性发作，17例（56.7%）为全身性癫痫样发作。心电图参数（PR间期、QTc、QT间期及QRS时限）的比较显示，治疗六个月时PR间期及QTc值缩短，尽管变化无统计学意义。治疗前与治疗六个月时的心电图参数在性别及癫痫类型方面未观察到显著差异（p > 0.05）。