一个臂旁核到杏仁核的回路决定了躯体感觉加工的半球侧化。
A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing.
机构信息
Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania; Department of Neuroscience and Center for Advanced Pain Studies, The University of Texas at Dallas, Richardson, Texas; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland.
出版信息
Biol Psychiatry. 2023 Feb 15;93(4):370-381. doi: 10.1016/j.biopsych.2022.09.010. Epub 2022 Sep 16.
BACKGROUND
The central amygdala (CeA) is a bilateral hub of pain and emotional processing with well-established functional lateralization. We reported that optogenetic manipulation of neural activity in the left and right CeA has opposing effects on bladder pain.
METHODS
To determine the influence of calcitonin gene-related peptide (CGRP) signaling from the parabrachial nucleus on this diametrically opposed lateralization, we administered CGRP and evaluated the activity of CeA neurons in acute brain slices as well as the behavioral signs of bladder pain in the mouse.
RESULTS
We found that CGRP increased firing in both the right and left CeA neurons. Furthermore, we found that CGRP administration in the right CeA increased behavioral signs of bladder pain and decreased bladder pain-like behavior when administered in the left CeA.
CONCLUSIONS
These studies reveal a parabrachial-to-amygdala circuit driven by opposing actions of CGRP that determines hemispheric lateralization of visceral pain.
背景
杏仁中央核（CeA）是疼痛和情绪处理的双侧中枢，其功能具有明确的侧化定位。我们曾报道，光遗传学操纵 CeA 的左右两侧神经活动对膀胱疼痛具有相反的影响。
方法
为了确定来自臂旁核的降钙素基因相关肽（CGRP）信号对这种截然相反的侧化的影响，我们给予 CGRP 并在急性脑切片中评估 CeA 神经元的活动，以及在小鼠中评估膀胱疼痛的行为征象。
结果
我们发现 CGRP 增加了右侧和左侧 CeA 神经元的放电。此外，我们发现给予右侧 CeA 的 CGRP 增加了膀胱疼痛的行为征象，而给予左侧 CeA 的 CGRP 则减少了膀胱疼痛样行为。
结论
这些研究揭示了一个由 CGRP 的相反作用驱动的臂旁核-杏仁核回路，该回路决定了内脏疼痛的半球侧化。
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