Paul Blesson K, Nunez-Ordaz Maria Isabel, Samuel Joseph R, Kolber Benedict J
Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, United States.
Neurobiol Pain. 2025 Jun 27;18:100190. doi: 10.1016/j.ynpai.2025.100190. eCollection 2025 Jul-Dec.
The amygdala integrates polymodal information including nociceptive stimuli. It is implicated as a key node in regulating both sensory-discriminative and emotional-affective aspects of pain and central sensitization. While central sensitization mechanisms in persistent pain are not completely understood, studying the neuronal properties exhibited by the amygdala neurons within their functional context, in this case, nociception, is important. Such studies can shed light on the behavior-modulating potential of the amygdala. In the last twenty years, multiple laboratories have begun the process of dissecting the cell-type specific activity involved in amygdala function. This review surveys these electrophysiological properties of neurons from different amygdala nuclei, cell types and circuitry studied so far, in the context of nociception and injury. A population-level accounting of these cell types provides greater insight into identifying specific targets to develop interventions for pain-mediated affective conditions.
杏仁核整合包括伤害性刺激在内的多模态信息。它被认为是调节疼痛的感觉辨别和情绪情感方面以及中枢敏化的关键节点。虽然持续性疼痛中的中枢敏化机制尚未完全明确，但在其功能背景下，即伤害感受的背景下，研究杏仁核神经元所表现出的神经元特性很重要。此类研究有助于揭示杏仁核调节行为的潜力。在过去二十年中，多个实验室已开始剖析参与杏仁核功能的细胞类型特异性活动。本综述在伤害感受和损伤的背景下，概述了迄今为止所研究的来自不同杏仁核核团、细胞类型和神经回路的神经元的这些电生理特性。对这些细胞类型进行群体水平的统计，有助于更深入地确定特定靶点，从而开发针对疼痛介导的情感状况的干预措施。
