Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China,
Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Dermatology. 2023;239(2):287-298. doi: 10.1159/000527461. Epub 2022 Dec 7.
Interstitial granulomatous dermatitis (IGD) and palisaded neutrophilic granulomatous dermatitis (PNGD) are uncommon presentations of reactive granulomatous dermatitis. Histologic lesions characterized by IGD/PNGD patterns have been associated with systemic diseases, causing an unmet need for revealing clinical correlates.
The aim of this study was to unravel the systemic diseases beyond dermatitis of IGD/PNGD.
This study analyzed data from case studies, case series, and retrospective cohorts by searching PubMed, Embase, Web of Science, and the Cochrane Library, with no start date or language restrictions on Sep 4, 2021.
One hundred ninety-six publications were included (458 cases in total, 216 with details). Systemic diseases associated with IGD/PNGD were classified into 5 groups. Autoimmune disorders (n = 103, 47.6%) including rheumatoid arthritis (n = 51, 23.6%), systemic lupus erythematosus (n = 20, 9.3%), and others were the most common across all underlying diseases, followed by drug eruption (n = 52, 24.1%) such as tumor necrotic factor inhibitor reaction (n = 18, 8.3%) and malignancies (n = 27, 12.5%) such as hematologic malignancy (n = 20, 9.3%). The rest were infectious diseases (n = 12, 5.6%) and accidental conditions (n = 3, 1.4%).
IGD/PNGD might be associated with autoimmune disorders, drug eruption, malignancies, infectious diseases, and accidental conditions. Patients with IGD/PNGD need further follow-up.
间质性肉芽肿性皮炎（IGD）和栅栏状中性粒细胞肉芽肿性皮炎（PNGD）是反应性肉芽肿性皮炎的罕见表现。具有 IGD/PNGD 模式的组织学病变与系统性疾病相关，因此需要揭示其临床相关性。
本研究旨在阐明 IGD/PNGD 之外的系统性疾病。
本研究通过搜索 PubMed、Embase、Web of Science 和 Cochrane Library，分析了病例研究、病例系列和回顾性队列研究的数据，无起始日期或语言限制，截止日期为 2021 年 9 月 4 日。
共纳入 196 篇文献（共 458 例，其中 216 例有详细资料）。与 IGD/PNGD 相关的系统性疾病分为 5 组。自身免疫性疾病（n = 103，47.6%），包括类风湿关节炎（n = 51，23.6%）、系统性红斑狼疮（n = 20，9.3%）和其他疾病；药物反应（n = 52，24.1%），如肿瘤坏死因子抑制剂反应（n = 18，8.3%）和恶性肿瘤（n = 27，12.5%），如血液系统恶性肿瘤（n = 20，9.3%）。其余为感染性疾病（n = 12，5.6%）和意外情况（n = 3，1.4%）。
IGD/PNGD 可能与自身免疫性疾病、药物反应、恶性肿瘤、感染性疾病和意外情况有关。IGD/PNGD 患者需要进一步随访。
