Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford, UK.
Br J Cancer. 2023 Feb;128(3):419-420. doi: 10.1038/s41416-022-02075-z. Epub 2022 Dec 7.
Two early papers expressing conflicting views on the occurrence of effective immune attack against cancers stimulate an analysis of the gradual development of an understanding of tumour biology. This understanding has led to the development of the strikingly effective check point blocking and CART anti-cancer immunotherapies, and the promise of more widely applicable therapies based on T cell attracting genetically engineered monoclonal antibodies.
两篇早期论文对癌症是否会发生有效免疫攻击这一观点提出了相互矛盾的看法,这激发了人们对肿瘤生物学逐渐发展的认识进行分析。这种认识导致了非常有效的检查点阻断和嵌合抗原受体 T 细胞(CAR-T)抗癌免疫疗法的发展,并为基于 T 细胞吸引基因工程单克隆抗体的更广泛应用疗法带来了希望。