Department of Urology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-Ro, Gangnam-Gu, Seoul, 06273, Republic of Korea.
Sci Rep. 2022 Dec 7;12(1):21171. doi: 10.1038/s41598-022-25748-4.
This study investigated the efficacy of the elastography strain ratio (ESR) as a predictor of prostate cancer (PCa) in targeted prostate biopsy. In total, 257 patients who underwent magnetic resonance imaging-targeted biopsy were enrolled. Before biopsy, we placed regions of interest (zone A and B) in the lesion and levator ani. The ESR was measured as zone A/zone B. Multivariate analyses were performed to predict PCa and clinically significant PCa. There were 206 (71.5%) positive cancer lesions. No difference in digit rectal examination findings was found between patients with and without PCa. For predicting clinically significant PCa, an ESR ≥ 6.8 was significantly higher in the PCa (+) group than in the PCa (-) group (p < 0.001). The area under the receiver operating characteristic curve (AUC) for the conventional variables (model 1) plus the ESR was 0.845, which was significantly higher than that for model 1 (p = 0.001). In prostate imaging reporting and data system score 3 lesions, an ESR ≥ 4.6 was a significant predictor of PCa (p = 0.002). The AUC in model 1 plus the ESR was 0.856, which was significantly higher than that in model 1 alone (p = 0.017). The ESR is useful for predicting clinically significant PCa.
本研究旨在探讨超声弹性成像应变率（ESR）在磁共振成像靶向前列腺活检中预测前列腺癌（PCa）的价值。共纳入 257 例行磁共振成像靶向活检的患者。在活检前，我们在病变和肛提肌部位的感兴趣区（A 区和 B 区）进行了定位。ESR 测量方法为 A 区/ B 区。进行多变量分析以预测 PCa 和临床显著 PCa。共发现 206 个（71.5%）阳性癌灶。PCa 患者和非 PCa 患者的直肠指诊结果无差异。对于预测临床显著 PCa，ESR≥6.8 在 PCa（+）组显著高于 PCa（-）组（p<0.001）。常规变量（模型 1）加 ESR 的受试者工作特征曲线下面积（AUC）为 0.845，显著高于模型 1（p=0.001）。在前列腺影像报告和数据系统评分 3 级病变中，ESR≥4.6 是 PCa 的显著预测因素（p=0.002）。模型 1 加 ESR 的 AUC 为 0.856，显著高于模型 1（p=0.017）。ESR 有助于预测临床显著 PCa。
