Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Immunol. 2022 Nov 21;13:1037124. doi: 10.3389/fimmu.2022.1037124. eCollection 2022.
Human papillomaviruses (HPVs) have been recognized as the etiologic agents of various cancers and are called HPV-driven cancers. Concerning HPV-mediated carcinogenic action, gene therapy can cure cancer at the molecular level by means of the correction of specific genes or sites. CRISPR-Cas9, as a novel genetic editing technique, can correct errors in the genome and change the gene expression and function in cells efficiently, quickly, and with relative ease. Herein, we overviewed studies of CRISPR-mediated gene remedies for HPV-driven cancers and summarized the potential applications of CRISPR-Cas9 in gene therapy for cancer.
人乳头瘤病毒（HPV）已被确认为多种癌症的病原体，被称为 HPV 驱动的癌症。关于 HPV 介导的致癌作用，基因治疗可以通过纠正特定基因或位点，从分子水平上治愈癌症。CRISPR-Cas9 作为一种新型的基因编辑技术，可以有效地、快速地、相对容易地纠正基因组中的错误，并改变细胞中的基因表达和功能。在此，我们综述了 CRISPR 介导的 HPV 驱动型癌症基因治疗研究，并总结了 CRISPR-Cas9 在癌症基因治疗中的潜在应用。
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