Li Meng, Li Zheng, Yu Danni, Wang Ming, Wang Dong, Wang Bing
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, P. R. China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, P. R. China.
Chemistry. 2023 Mar 7;29(14):e202202930. doi: 10.1002/chem.202202930. Epub 2023 Feb 8.
Recently, extensive efforts have been devoted to the development of the second near-infrared bio-window (NIR-II, 1000-1700 nm) theranostic agents owing to the excellent tissue-penetration capability of NIR-II light. The exploration of organic NIR-II photothermal therapy materials, especially those with absorption peak over 1000 nm, is an appealing yet significantly challenging task. Herein, we have designed conjugated polymer nanoparticles (PIS NPs) with NIR-II absorption peak at 1026 nm through a combined strategy of introducing quinoid donor-acceptor (D-A) structures, constructing intramolecular "conformational locks" and extending the conjugation area to narrow the band gap. Irradiated at 1064 nm, PIS NPs showed remarkable photothermal conversion performance for efficient photothermal ablation of tumor cells in vitro and in vivo. This study provides useful insights into the rational design of organic NIR-II photothermal agents based on multiple strategies.
近年来，由于近红外二区（NIR-II，1000 - 1700 nm）光具有出色的组织穿透能力，人们致力于开发用于诊疗的近红外二区生物窗口的诊疗试剂。探索有机近红外二区光热治疗材料，特别是那些吸收峰超过1000 nm的材料，是一项既吸引人又极具挑战性的任务。在此，我们通过引入醌型供体 - 受体（D-A）结构、构建分子内“构象锁”以及扩展共轭区域以缩小带隙的组合策略，设计了吸收峰位于1026 nm的近红外二区共轭聚合物纳米颗粒（PIS NPs）。在1064 nm波长照射下，PIS NPs表现出卓越的光热转换性能，能够在体外和体内有效地光热消融肿瘤细胞。该研究为基于多种策略合理设计有机近红外二区光热剂提供了有益的见解。
