Departament de Psicología Bàsica, Clínica i Psicobiología, Universitat Jaume I, Castelló de la Plana, Spain.
Grupo de Neuroimagen y Psicofisiología, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Castelló, Spain.
Arch Clin Neuropsychol. 2023 Jul 25;38(5):724-738. doi: 10.1093/arclin/acac096.
Depressive disorder occurs in up to 50% of persons with Multiple Sclerosis (PwMS). Accurate assessment of depression in MS is essential in clinical settings because depressive symptomatology can affect the clinical course of the disease.
We translated, adapted, and tested the Spanish version of the Chicago Multiscale Depression Inventory (CMDI), a specific test to assess depression in neurological disorders. We compare our results with those obtained with previous versions of the questionnaire (English and Italian). Finally, we also analyze the relationship between the results obtained on the CMDI and demographic, clinical, and cognitive variables.
The results obtained with the Spanish version of the CMDI were similar to those observed in previous published versions. We also observed higher depression scores in PwMS (especially in progressive forms) compared with healthy controls. Moreover, depression symptomatology was related to higher disability and fatigue and worse cognitive performance in PwMS.
The results support the validity of the CDMI in the Spanish population, as well as the association between depression and other characteristic symptoms of MS. These findings also emphasize the importance of good assessment and multidisciplinary treatment of depression in PwMS.
多发性硬化症（PwMS）患者中有多达 50%的人会出现抑郁障碍。在临床环境中，对 MS 患者的抑郁症状进行准确评估至关重要，因为抑郁症状可能会影响疾病的临床进程。
我们翻译、改编并测试了用于评估神经障碍患者抑郁症状的专用测试——芝加哥多尺度抑郁量表（CMDI）的西班牙语版本。我们将研究结果与先前版本问卷（英语和意大利语）的结果进行了比较。最后，我们还分析了 CMDI 结果与人口统计学、临床和认知变量之间的关系。
CMDIS 西班牙语版本的结果与之前发表的版本相似。与健康对照组相比，PwMS （尤其是进展型）的抑郁评分更高。此外，PwMS 的抑郁症状与更高的残疾、疲劳和更差的认知表现相关。
研究结果支持 CDMI 在西班牙人群中的有效性，以及抑郁与 MS 其他特征症状之间的关联。这些发现还强调了对 PwMS 患者进行良好评估和多学科治疗抑郁的重要性。
