Solari A, Motta A, Mendozzi L, Aridon P, Bergamaschi R, Ghezzi A, Mancardi G L, Milanese C, Montanari E, Pucci E
Laboratory of Epidemiology, C. Besta National Neurological Institute, Via Celoria 11, I-20133, Milan, Italy.
Neurol Sci. 2004 Feb;24(6):375-83. doi: 10.1007/s10072-003-0192-1.
Depression is the commonest psychiatric disturbance in people with multiple sclerosis (MS), with prevalence higher than in the general population and other chronic diseases. However, accurate assessment of depressive symptoms can be biased by somatic symptoms which are part of both MS and depression. We translated and adapted into Italian the Chicago multiscale depression inventory (CMDI) and assessed its acceptability, internal consistency and test-retest reliability in 213 MS outpatients and 213 individually matched healthy controls. The questionnaire was also tested in 32 people with major depression. Acceptability, internal consistency, and test-retest reliability were good overall. We found greater odds for depressive symptoms in people with MS than healthy controls, with highest odds ratio for somatic symptoms (vegetative subscale). The Italian CMDI is characterized by good acceptability, internal consistency, and test-retest reliability. These findings support the use of the CMDI in Italian subjects with MS to screen for and follow depressive symptoms.
抑郁症是多发性硬化症（MS）患者中最常见的精神障碍，其患病率高于普通人群和其他慢性病患者。然而，抑郁症状的准确评估可能会受到躯体症状的影响而产生偏差，这些躯体症状既是MS的一部分，也是抑郁症的一部分。我们将芝加哥多维度抑郁量表（CMDI）翻译成意大利语并进行了改编，在213名MS门诊患者和213名个体匹配的健康对照中评估了其可接受性、内部一致性和重测信度。该问卷也在32名重度抑郁症患者中进行了测试。总体而言，可接受性、内部一致性和重测信度良好。我们发现MS患者出现抑郁症状的几率高于健康对照，其中躯体症状（植物神经子量表）的比值比最高。意大利语版CMDI具有良好的可接受性、内部一致性和重测信度。这些发现支持在意大利的MS患者中使用CMDI来筛查和跟踪抑郁症状。
