College of Chemistry and Chemical Engineering, Anhui University, Hefei, China.
Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, China.
J Biomater Sci Polym Ed. 2023 Jun;34(9):1157-1170. doi: 10.1080/09205063.2022.2157673. Epub 2022 Dec 18.
Polysaccharides are widely used in biomedicine because of their unique biological activity, low costs, and easy-to-obtain. In this paper, polysaccharide (BSP) was integrated into waterborne polyurethane (WPU) to prepare a series of WPU-BSP (WPUB) hydrogels. The hydrogels showed good compressive strength, water absorption and retention ability, which are favorable for wound healing. Among them, the WPUB4 gel has the best comprehensive performances, including a compressive strength of 1.07 MPa, a swelling rate of 16.3, a reasonable WVRT of 2013 g/m/day, and a long water retention time. About the biocompatibility, moreover, the WPUB4 hydrogel has a low hemolysis rate of 2.47%, a hydroxyl radical clearance rate of 35.5%, and little cytotoxicity with cell viability of 101.4%. Most importantly, the WPUB hydrogel dressings showed excellent ability in promoting wound healing. Compared to the conventional gauze, the wound surface area of mice treated with WPUB hydrogel was significantly reduced on day 3 after surgery and the wounds were healed on day 7. The new skin had a thicker epidermis and more capillaries. The WPUB hydrogels integrating BSP are promising to function as wound dressings.
多糖因其独特的生物活性、低成本和易于获取而广泛应用于生物医学领域。本文将多糖（BSP）整合到水性聚氨酯（WPU）中，制备了一系列 WPU-BSP（WPUB）水凝胶。水凝胶表现出良好的抗压强度、吸水和保水能力，有利于伤口愈合。其中，WPUB4 凝胶具有最佳的综合性能，包括 1.07 MPa 的抗压强度、16.3 的溶胀率、2013 g/m/天的合理 WVRT 和较长的保水时间。此外，关于生物相容性，WPUB4 水凝胶具有较低的溶血率 2.47%、35.5%的羟基清除率和较低的细胞毒性，细胞活力为 101.4%。最重要的是，WPUB 水凝胶敷料表现出优异的促进伤口愈合能力。与传统纱布相比，用 WPUB 水凝胶处理的小鼠的伤口表面积在手术后第 3 天显著减少，第 7 天伤口愈合。新皮肤的表皮较厚，毛细血管较多。整合 BSP 的 WPUB 水凝胶有望作为伤口敷料。
