Department of Pediatrics, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Pediatric Intensive Care Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Acta Paediatr. 2023 Mar;112(3):477-482. doi: 10.1111/apa.16623. Epub 2022 Dec 20.
The major clinical manifestations multisystem inflammatory syndrome in children (MIS-C) are fever, gastrointestinal and cardiac. The aim of this study was to describe MIS-C in a series of patients who presented primarily with cervical manifestations.
We retrospectively reviewed medical records of all patients who met the Centers for Disease Control and Prevention and World Health Organization MIS-C diagnostic criteria treated at Hadassah-Hebrew University Medical Center between April 2020 and September 2021.
Of 37 children diagnosed with MIS-C (median age: 10.2 years, range 1.5-18 years, 20 male) five, 13.5% (median age: 14.4 years, range 9.2-17.5 years) presented with cervical symptoms mimicking neck infections. One was hospitalised with a working diagnosis of retropharyngeal abscess, and four with acute cervical lymphadenitis that did not respond to early antibiotic treatment. All developed full MIS-C phenotype.
MIS-C may present as cervical inflammation. An ill-appearing child with symptoms and/or signs of cervical inflammation should be evaluated for clinical and laboratory features of MIS-C, thereby facilitating prompt treatment of this potentially fatal disorder.
儿童多系统炎症综合征（MIS-C）的主要临床表现为发热、胃肠道和心脏症状。本研究旨在描述一组以颈部表现为主要表现的 MIS-C 患者。
我们回顾性分析了 2020 年 4 月至 2021 年 9 月在哈达萨-希伯来大学医学中心接受治疗的符合美国疾病控制与预防中心和世界卫生组织 MIS-C 诊断标准的所有患者的病历。
37 名被诊断为 MIS-C 的儿童中（中位年龄：10.2 岁，范围 1.5-18 岁，男性 20 名），5 名（中位年龄：14.4 岁，范围 9.2-17.5 岁）表现为类似颈部感染的颈部症状。1 名患儿因疑似咽后脓肿住院，4 名患儿因急性颈淋巴结炎且早期抗生素治疗无效而住院。所有患儿均出现典型的 MIS-C 表现。
MIS-C 可表现为颈部炎症。对于出现颈部炎症的症状和/或体征且表现不佳的患儿，应评估其是否存在 MIS-C 的临床和实验室特征，从而及时治疗这种潜在致命疾病。
