Shandong Tiantai Environmental Technology Co., Jinan 250101, China.
School of Environmental Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
Int J Environ Res Public Health. 2022 Nov 24;19(23):15632. doi: 10.3390/ijerph192315632.
Livestock farming has led to the rapid accumulation of antibiotic resistance genes in the environment. Chloramphenicol (CAP) was chosen as a model compound to investigate its degradation during electrochemical treatment. Ti/PbO electrodes were prepared using electrodeposition. The prepared Ti/PbO-La electrodes had a denser surface and a more complete PbO crystal structure. Ti/PbO-Co electrodes exhibited improved electrochemical catalytic activity and lifetime in practice. The impact of different conditions on the effectiveness of CAP electrochemical degradation was investigated, and the most favorable conditions were identified (current density: I = 15.0 mA/cm, electrolyte concentration: c = 0.125 mol/L, solution pH = 5). Most importantly, we investigated the effects of the different stages of treatment with CAP solutions on the abundance of resistance genes in natural river substrates (, , , and ). When CAP was completely degraded (100% TOC removal), no effect on resistance gene abundance was observed in the river substrate; incomplete CAP degradation significantly increased the absolute abundance of resistance genes. This suggests that when treating solutions with antibiotics, they must be completely degraded (100% TOC removal) before discharge into the environment to reduce secondary pollution. This study provides insights into the deep treatment of wastewater containing antibiotics and assesses the environmental impact of the resulting treated wastewater.
畜牧业的发展导致了环境中抗生素耐药基因的快速积累。本研究选择氯霉素（CAP）作为模型化合物，考察其在电化学处理过程中的降解情况。采用电沉积法制备 Ti/PbO 电极。制备的 Ti/PbO-La 电极表面更致密，PbO 晶体结构更完整。Ti/PbO-Co 电极在实际应用中表现出更好的电化学催化活性和稳定性。考察了不同条件对 CAP 电化学降解效果的影响，确定了最有利的条件（电流密度：I=15.0 mA/cm2，电解质浓度：c=0.125 mol/L，溶液 pH=5）。更重要的是，我们研究了 CAP 溶液在不同处理阶段对天然河流底泥中耐药基因丰度的影响（、、、和）。当 CAP 完全降解（TOC 去除率 100%）时，河流底泥中耐药基因丰度没有受到影响；而 CAP 不完全降解则显著增加了耐药基因的绝对丰度。这表明在处理含有抗生素的废水时，必须将其完全降解（TOC 去除率 100%）后才能排放到环境中，以减少二次污染。本研究为深入处理含抗生素废水提供了思路，并评估了处理后废水的环境影响。
