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南极真菌菌株 SF-7343 中的 14-甲氧基交替 C 通过调节 NF-κB 和 JAK2/STAT3 对 HaCaT 人角质形成细胞发挥抗炎作用。

Anti-Inflammatory Effects Exerted by 14-Methoxyalternate C from Antarctic Fungal Strain sp. SF-7343 via the Regulation of NF-κB and JAK2/STAT3 in HaCaT Human Keratinocytes.

机构信息

College of Pharmacy, Chosun University, Dong-gu, Gwangju 61452, Republic of Korea.

Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.

出版信息

Int J Mol Sci. 2022 Nov 24;23(23):14642. doi: 10.3390/ijms232314642.

DOI:10.3390/ijms232314642
PMID:36498968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9740060/
Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a profound negative impact on patients' quality of life. Four known secondary fungal metabolites were found in the chemical study of the Antarctic fungus sp. SF-7343, including 14-methoxyalternate C (), 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (), 3,8,10-trihydroxy-4-methoxy-6-methylbenzocoumarin (), and alternariol monomethyl ether (). Additionally, we identified the skin anti-inflammatory composition from the SF-7343 strain. Interleukin-8 and -6 Screening results showed that compound inhibited IL-8 and IL-6 in tumor necrosis factor-α/interferon-γ stimulated HaCaT cells. Compound showed inhibitory effects on MDC and RANTES. It also downregulated the expression of intercellular adhesion molecule-1 (ICAM-1) and upregulated the expression of involucrin. The results of the mechanistic study showed that compound inhibited the nuclear translocation of nuclear factor-kappa B p65 and STAT3. In conclusion, this study demonstrates the potential of the Antarctic fungal strain SF-7343 as a bioactive resource to inhibit skin inflammation, such as AD.

摘要

特应性皮炎（AD）是一种慢性炎症性皮肤病，对患者的生活质量有深远的负面影响。在对南极真菌 sp. SF-7343 的化学研究中发现了四种已知的次级真菌代谢产物，包括 14-甲氧基交替 C（）、5'-甲氧基-6-甲基-联苯-3,4,3'-三醇（）、3,8,10-三羟基-4-甲氧基-6-甲基苯并[c]香豆素（）和交替醇单甲醚（）。此外，我们从 SF-7343 菌株中鉴定出具有皮肤抗炎作用的成分。白细胞介素-8 和白细胞介素-6 筛选结果表明，化合物 抑制肿瘤坏死因子-α/干扰素-γ 刺激的 HaCaT 细胞中 IL-8 和 IL-6 的产生。化合物 对 MDC 和 RANTES 具有抑制作用。它还下调细胞间黏附分子-1（ICAM-1）的表达，上调外皮蛋白的表达。机制研究结果表明，化合物 抑制核因子-κB p65 和 STAT3 的核转位。总之，这项研究表明南极真菌菌株 SF-7343 具有作为抑制皮肤炎症（如 AD）的生物活性资源的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b059/9740060/28a3c861db79/ijms-23-14642-g006.jpg
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