State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China.
Department of Chemistry and Molecular Biology, University of Gothenburg, 41390 Gothenburg, Sweden.
Int J Mol Sci. 2022 Dec 5;23(23):15327. doi: 10.3390/ijms232315327.
The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The spatiotemporal regulation mechanisms of APC/C in distinct cell cycle transitions are no longer mysterious, and the components of this protein complex are gradually identified and characterized. Given the close relationship between the cell cycle and lifespan, it is urgent to understand the roles of APC/C in lifespan regulation, but this field still seems to have not been systematically summarized. Furthermore, although several reviews have reported the roles of APC/C in cancer, there are still gaps in the summary of its roles in other age-related diseases. In this review, we propose that the APC/C is a novel cellular ageing regulator based on its indispensable role in the regulation of lifespan and its involvement in age-associated diseases. This work provides an extensive review of aspects related to the underlying mechanisms of APC/C in lifespan regulation and how it participates in age-associated diseases. More comprehensive recognition and understanding of the relationship between APC/C and ageing and age-related diseases will increase the development of targeted strategies for human health.
后期促进复合物/细胞周期蛋白体（APC/C）是一种复杂的细胞成分，在调节真核生物的细胞周期过程中起着重要作用。APC/C 在不同细胞周期转换中的时空调控机制已不再神秘，该蛋白复合物的组成部分也逐渐被鉴定和描述。鉴于细胞周期与寿命之间的密切关系，迫切需要了解 APC/C 在寿命调节中的作用，但该领域似乎仍未得到系统总结。此外，尽管有几项综述报道了 APC/C 在癌症中的作用，但在总结其在其他与年龄相关的疾病中的作用方面仍存在差距。在这篇综述中，我们提出 APC/C 是一种新型的细胞衰老调控因子，基于其在寿命调节中的不可或缺作用及其在与年龄相关的疾病中的参与。这项工作广泛综述了 APC/C 调节寿命的潜在机制及其参与与年龄相关的疾病的相关方面。更全面地认识 APC/C 与衰老和与年龄相关的疾病之间的关系，将增加针对人类健康的靶向策略的发展。
