APC/C 泛素连接酶：在肿瘤发生中的功能和机制。
APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis.
机构信息
Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University Wexner School of Medicine, 420 W 12(th) Avenue, Columbus, OH, 43210, USA.
Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University Wexner School of Medicine, 420 W 12(th) Avenue, Columbus, OH, 43210, USA.
出版信息
Semin Cancer Biol. 2020 Dec;67(Pt 2):80-91. doi: 10.1016/j.semcancer.2020.03.001. Epub 2020 Mar 9.
Abstract
The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the role of APC/C coactivators, Cdh1 and Cdc20, in cancer initiation and development. We summarize the current state of knowledge regarding APC/C structure and function, as well as the distinct ways Cdh1 and Cdc20 are dysregulated in human cancer. We also discuss APC/C inhibitors, novel approaches for targeting the APC/C as a cancer therapy, and areas for future work.
摘要
后期促进复合物/细胞周期蛋白（APC/C）是一种进化上保守的蛋白质复合物，对于细胞分裂至关重要，因为它在调节从中期到后期的有丝分裂转换中发挥作用。在这篇综述中，我们强调了最近的工作，这些工作阐明了我们对 APC/C 共激活因子 Cdh1 和 Cdc20 在癌症发生和发展中的作用的理解。我们总结了目前关于 APC/C 结构和功能的知识，以及 Cdh1 和 Cdc20 在人类癌症中失调的不同方式。我们还讨论了 APC/C 抑制剂、作为癌症治疗靶向 APC/C 的新方法以及未来的工作领域。
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