越南感染间日疟原虫的美国黑人的达菲血型表型

The Duffy blood group phenotype in American blacks infected with Plasmodium vivax in Vietnam.

作者信息

Miller L H, McGinniss M H, Holland P V, Sigmon P

出版信息

Am J Trop Med Hyg. 1978 Nov;27(6):1069-72. doi: 10.4269/ajtmh.1978.27.1069.

DOI:10.4269/ajtmh.1978.27.1069

Abstract

We determined blood group phenotypes of 13 blacks who were infected with Plasmodium vivax in Vietnam. All were Duffy blood group positive as compared to 40--50% Duffy positive in surveys of black blood donors in the United States. The probability that 13 of 13 were Duffy positive by chance alone was P less than 0.001. All other blood groups occurred at the expected frequency. This study is further support for the hypothesis that the Duffy negative genotype (FyFy) is the basis for resistance of blacks to P. vivax.

摘要

我们测定了13名在越南感染间日疟原虫的黑人的血型表型。与美国黑人献血者调查中40%-50%的达菲血型阳性率相比，所有这些人达菲血型均为阳性。仅靠偶然因素13人全部为达菲阳性的概率P小于0.001。所有其他血型出现的频率均在预期范围内。这项研究进一步支持了以下假说：达菲阴性基因型（FyFy）是黑人对间日疟原虫具有抵抗力的基础。