Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 40402, Taiwan.
Core Facility Center, Office of Research and Development, Taipei Medical University, Taipei 110301, Taiwan.
Molecules. 2022 Dec 5;27(23):8548. doi: 10.3390/molecules27238548.
Six new polyoxygenated terpenoids, podovirosanes A-F (-), and two known polyketides ( and ) were isolated from the roots of . Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds , , , and were found to reduce the phosphorylation levels of NF-B p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells.
从 的根部分离得到了六个新的多氧化萜类化合物，podovirosanes A-F（-），和两个已知的聚酮化合物（ 和 ）。通过光谱分析以及计算计算，包括 ECD 光谱的 TDDFT 计算和与 DP4+ 概率分析相结合的 GIAO NMR 计算，推导了它们的结构和绝对构型。发现化合物 、 、 和 可降低 SARS-CoV-2 假病毒刺激 PMA 分化的 THP-1 细胞中 NF-B p65 的磷酸化水平。
