Han Jiaojiao, Wu Qiaoli, Wang Ziyan, Lu Chenyang, Zhou Jun, Li Ye, Ming Tinghong, Zhang Zhen, Su Xiurong
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China.
School of Marine Science, Ningbo University, Ningbo, China.
J Sci Food Agric. 2023 Jun;103(8):4077-4084. doi: 10.1002/jsfa.12383. Epub 2023 Jan 24.
Previous studies have shown that anserine can alleviate hyperuricemia by changing the fecal microbiota of hyperuricemic mice.
However, the fecal microbiota could not fully represent the distribution of the whole gut microbiota. Knowing the spatial distribution of the gastrointestinal tract microbiota is therefore important for understanding its action in the occurrence and remission of hyperuricemia.
This study provides a comprehensive map of the most common bacterial communities that colonize different parts of the mouse gastrointestinal tract (stomach, duodenum, ileum, cecum, and colon) using a modern methodological approach.
The stomach, colon, and cecum showed the greatest richness and diversity in bacterial species. Three clusters of bacterial populations were observed along the digestive system: (1) in the stomach, (2) in the duodenum and ileum, and (3) in the colon and cecum. A high purine solution changed the composition and abundance of the digestive tract microbiota, and anserine relieved hyperuricemia by restoring the homeostasis of the digestive tract microbiota, especially improving the abundance of probiotics in the digestive tract.
This could be the starting point for further research on the regulation of hyperuricemia by gut microbiota with the ultimate goal of promoting health and welfare. © 2022 Society of Chemical Industry.
先前的研究表明，鹅肌肽可通过改变高尿酸血症小鼠的粪便微生物群来缓解高尿酸血症。
然而，粪便微生物群不能完全代表整个肠道微生物群的分布。因此，了解胃肠道微生物群的空间分布对于理解其在高尿酸血症发生和缓解中的作用很重要。
本研究采用现代方法绘制了一幅全面的地图，展示了定殖于小鼠胃肠道不同部位（胃、十二指肠、回肠、盲肠和结肠）的最常见细菌群落。
胃、结肠和盲肠的细菌种类最为丰富多样。沿消化系统观察到三类细菌种群：（1）在胃中，（2）在十二指肠和回肠中，以及（3）在结肠和盲肠中。高嘌呤溶液改变了消化道微生物群的组成和丰度，鹅肌肽通过恢复消化道微生物群的稳态来缓解高尿酸血症，尤其是提高消化道中益生菌的丰度。
这可能是进一步研究肠道微生物群对高尿酸血症调节作用的起点，最终目标是促进健康和福祉。© 2022化学工业协会。
