circPHF16 通过调控 miR-581/RNF128/Wnt/β-catenin 通路抑制前列腺癌转移。
circPHF16 suppresses prostate cancer metastasis via modulating miR-581/RNF128/Wnt/β-catenin pathway.
机构信息
Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
出版信息
Cell Signal. 2023 Feb;102:110557. doi: 10.1016/j.cellsig.2022.110557. Epub 2022 Dec 9.
Circular RNAs (circRNAs) have been recognized as important regulators in tumorigenesis. However, the specific role of circRNAs in prostate cancer is still largely unknown. Here, we identified that circPHF16 was downregulated in prostate cancer (PCa) tissues compared with normal tissues. Functionally, circPHF16 restrained prostate cancer metastasis both in vivo and in vitro. Mechanistically, circPHF16 directly interacted with miR-581, leading to the downregulation of ring finger protein 128 (RNF128) and inhibiting the metastatic ability of PCa. Furthermore, circPHF16-dependent upregulation of RNF128 inactivated Wnt/β-catenin signaling. In total, our findings revealed that circPHF16 suppressed prostate cancer metastasis through the circPHF16/miR-581/Wnt/β-catenin pathways.
环状 RNA（circRNAs）已被认为是肿瘤发生中的重要调节因子。然而，circRNAs 在前列腺癌中的具体作用仍在很大程度上未知。在这里，我们发现与正常组织相比，circPHF16 在前列腺癌（PCa）组织中表达下调。功能上，circPHF16 在体内和体外均抑制前列腺癌转移。在机制上，circPHF16 直接与 miR-581 相互作用，导致环指蛋白 128（RNF128）下调，并抑制 PCa 的转移能力。此外，circPHF16 依赖性上调 RNF128 使 Wnt/β-catenin 信号失活。总的来说，我们的研究结果表明，circPHF16 通过 circPHF16/miR-581/Wnt/β-catenin 通路抑制前列腺癌转移。
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