Department of Periodontology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, No. 22 ZhongGuanCun Nandajie, HaiDian District, Beijing, 100081, China.
Department of Stomatology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
BMC Oral Health. 2022 Dec 12;22(1):598. doi: 10.1186/s12903-022-02657-6.
Peri-implantitis was an inflammatory progress on the tissue around the implant. The Osteoprotegerin G1181C (rs2073618) polymorphism was reported to be related to the increased risk of the peri-implantitis, whereas another found no relationship. The present study was conducted to research the relationship between Osteoprotegerin rs2073618 polymorphism and peri-implantitis susceptibility.
The meta-analysis was performed according to the Preferred Reporting Items for Systematic reviews. Electronic databases including PubMed, Web of science, Springer Link and Embase (updated to April 15, 2022) were retrieved. The cohort study, case-control study or cross-sectional study focusing on the Osteoprotegerin rs2073618 polymorphism and peri-implantitis were retrieved. The data included basic information of each study and the genotype and allele frequencies of the cases and controls.
Three studies were finally included, including 160 cases and 271 controls. Allelic model, homozygote model, recessive model, dominant model, and heterozygous model were established to assess the relationship between OPG rs2073618 polymorphism and peri-implantitis susceptibility. The Osteoprotegerin rs2073618 polymorphism was significantly associated with peri-implantitis in Recessive model and Homozygote model.
OPG rs2073618 polymorphism in Recessive model and Homozygote model was highly likely related to the risk of peri-implantitis. PROSPERO registration number: CRD42022320812.
种植体周围炎是发生在种植体周围组织的炎症进展。骨保护素 G1181C(rs2073618)多态性被报道与种植体周围炎的风险增加有关，而另一种则没有关系。本研究旨在研究骨保护素 rs2073618 多态性与种植体周围炎易感性的关系。
根据系统评价的首选报告项目进行荟萃分析。检索了电子数据库，包括 PubMed、Web of Science、Springer Link 和 Embase（更新至 2022 年 4 月 15 日）。检索了聚焦于骨保护素 rs2073618 多态性和种植体周围炎的队列研究、病例对照研究或横断面研究。数据包括每个研究的基本信息以及病例和对照的基因型和等位基因频率。
最终纳入了 3 项研究，共 160 例病例和 271 例对照。建立了等位基因模型、纯合子模型、隐性模型、显性模型和杂合子模型，以评估 OPG rs2073618 多态性与种植体周围炎易感性的关系。骨保护素 rs2073618 多态性在隐性模型和纯合子模型中与种植体周围炎显著相关。
OPG rs2073618 多态性在隐性模型和纯合子模型中与种植体周围炎的风险高度相关。PROSPERO 注册号：CRD42022320812。
