School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Small. 2023 Feb;19(7):e2205414. doi: 10.1002/smll.202205414. Epub 2022 Dec 11.
Osteosarcoma (OS) is the most serious bone malignancy, and the survival rate has not significantly improved in the past 40 years. Thus, it is urgent to develop a new strategy for OS treatment. Chemodynamic therapy (CDT) as a novel therapeutic method can destroy cancer cells by converting endogenous hydrogen peroxide (H O ) into highly toxic hydroxyl radicals (·OH). However, the therapeutic efficacy of CDT is severely limited by the low catalytic efficiency and overexpressed glutathione (GSH). Herein, an excellent nanocatalytic platform is constructed via a simple solvothermal method using F127 as a soft template to form the hollow copper ferrite (HCF) nanoparticle, followed by the coating of polydopamine on the surface and the loading of doxorubicin (DOX). The Fe and Cu released from HCF@polydopamine (HCFP) can deplete GSH through the redox reactions, and then trigger the H O to generate ·OH by Fenton/Fenton-like reaction, resulting in enhanced CDT efficacy. Impressively, the photothermal effect of HCFP can further enhance the efficiency of CDT and accelerate the release of DOX. Both in vitro and in vivo experiments reveal that the synergistic chemodynamic/photothermal/chemo-therapy exhibits a significantly enhanced anti-OS effect. This work provides a promising strategy for OS treatment.
骨肉瘤（OS）是最严重的骨恶性肿瘤，在过去的 40 年中，其生存率并没有显著提高。因此，迫切需要开发一种新的骨肉瘤治疗策略。化学动力学治疗（CDT）作为一种新的治疗方法，可以通过将内源性过氧化氢（H O ）转化为高毒性的羟基自由基（·OH）来破坏癌细胞。然而，CDT 的治疗效果受到其低催化效率和过表达谷胱甘肽（GSH）的严重限制。在此，通过简单的溶剂热法使用 F127 作为软模板构建了一个优秀的纳米催化平台，以形成中空的铜铁氧体（HCF）纳米颗粒，然后在表面涂覆聚多巴胺并负载阿霉素（DOX）。HCF@聚多巴胺（HCFP）中释放的 Fe 和 Cu 通过氧化还原反应消耗 GSH，然后通过 Fenton/Fenton 样反应将 H O 转化为·OH，从而增强 CDT 效果。令人印象深刻的是，HCFP 的光热效应可以进一步提高 CDT 的效率并加速 DOX 的释放。体外和体内实验均表明，协同化学动力学/光热/化疗表现出显著增强的抗骨肉瘤效果。这项工作为骨肉瘤的治疗提供了一种很有前途的策略。
