Ruan Wenting, Zhai Xixi, Guan Lin, Wei Xijin, Zhang Sishuo
Special Inspection Section, Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014, Shandong, China.
First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine Jinan 250014, Shandong, China.
Am J Transl Res. 2022 Nov 15;14(11):7852-7859. eCollection 2022.
To determine the expressions of serum adiponectin and visfatin in patients with hypertension and cerebrovascular accidents and to analyze the risk factors.
Data of 161 patients with hypertension treated in The Affiliated Hospital of Shandong University of Traditional Chinese Medicine from March 2019 to July 2021 were retrospectively analyzed. There were 72 patients with cerebrovascular accidents assigned to an occurrence group. The remaining 89 patients without cerebrovascular accidents were assigned to a non-occurrence group. The two groups were compared in terms of the coagulation function (activated partial thromboplastin time, prothrombin time, and fibrinogen), liver function (aspartate aminotransferase (AST), glutamic pyruvic transaminase (GPT), albumin and total bilirubin (TB)), blood lipid indexes (cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL)), serum adiponectin, and visfatin levels. Pearson's correlation coefficient was performed to analyze the correlation of serum adiponectin and visfatin with blood lipid indexes. Logistics regression was performed to analyze the risk factors of stroke in patients with hypertension.
The two groups were similar in terms of sex, age, education level, smoking, drinking, and diabetes histories (P>0.05). There were more patients ≥65 years old with body mass index ≥20 kg/m and with hyperlipidemia in the occurrence group than those in the non-occurrence group (P<0.05). The two groups were not notably different in activated partial thromboplastin time, prothrombin time, fibrinogen, AST, GPT, albumin, TB, total cholesterol, and HDL (P>0.05). The occurrence group showed significantly higher triglyceride, LDL and adiponectin levels, and a notably lower visfatin level than the non-occurrence group (P<0.05). Adiponectin showed a positive correlation with triglyceride and a negative association with LDL (P<0.05). Visfatin showed only a negative correlation with triglyceride (P<0.05), but no correlation with LDL (P>0.05). A multivariate logistics regression analysis reported that hyperlipidemia, triglyceride, LDL, adiponectin, and visfatin were independent risk factors for stroke in patients with hypertension (P<0.05).
Serum adiponectin and visfatin were differentially expressed in patients with both hypertension and stroke. Our regression analysis revealed that serum adiponectin and visfatin were independent risk factors for stroke in patients with hypertension.
测定高血压合并脑血管意外患者血清脂联素和内脂素的表达水平，并分析相关危险因素。
回顾性分析2019年3月至2021年7月在山东中医药大学附属医院接受治疗的161例高血压患者的数据。其中72例发生脑血管意外的患者被分配到发病组。其余89例未发生脑血管意外的患者被分配到未发病组。比较两组患者的凝血功能（活化部分凝血活酶时间、凝血酶原时间和纤维蛋白原）、肝功能（天冬氨酸氨基转移酶（AST）、谷丙转氨酶（GPT）、白蛋白和总胆红素（TB））、血脂指标（胆固醇、甘油三酯、高密度脂蛋白（HDL）、低密度脂蛋白（LDL））、血清脂联素和内脂素水平。采用Pearson相关系数分析血清脂联素和内脂素与血脂指标的相关性。进行Logistic回归分析以分析高血压患者发生脑卒中的危险因素。
两组患者在性别、年龄、教育程度、吸烟、饮酒和糖尿病史方面相似（P>0.05）。发病组中年龄≥65岁、体重指数≥20kg/m²且患有高脂血症的患者比未发病组多（P<0.05）。两组患者在活化部分凝血活酶时间、凝血酶原时间、纤维蛋白原、AST、GPT、白蛋白、TB、总胆固醇和HDL方面无显著差异（P>0.05）。发病组的甘油三酯、LDL和脂联素水平显著高于未发病组，而内脂素水平显著低于未发病组（P<0.05）。脂联素与甘油三酯呈正相关，与LDL呈负相关（P<0.05）。内脂素仅与甘油三酯呈负相关（P<0.05），与LDL无相关性（P>0.05）。多因素Logistic回归分析显示，高脂血症、甘油三酯、LDL、脂联素和内脂素是高血压患者发生脑卒中的独立危险因素（P<0.05）。
高血压合并脑卒中患者血清脂联素和内脂素表达存在差异。回归分析显示，血清脂联素和内脂素是高血压患者发生脑卒中的独立危险因素。
