Li Ying, Gu Xiufeng, Shi Yun, Li Jie, Wen Shangyu
Tianjin Fourth Central Hospital, Department of Cardiology, Tianjin, China.
J Med Biochem. 2024 Jun 15;43(4):597-604. doi: 10.5937/jomb0-45532.
The study aimed to explore the correlation between the angiotensin II (Ang II) gene and serum adiponectin expression in patients with cerebrovascular complications of H-type hypertension (HH) and its mechanism.
A total of 50 cases of outpatient patients in Tianjin Fourth Central Hospital were recruited from January 2022 to June 2023 and rolled into three groups according to their blood pressure and basic information, namely the HH cerebrovascular complications group, the non-H-type hypertension (NHH) group, and the healthy control (HC) group. Peripheral blood samples were taken; one sample was utilized to test for the Ang II gene and the methylation of Ang II, and the other sample was utilized to measure serum adiponectin levels to analyze the relationship between serum adiponectin level and Ang II in patients with cerebrovascular complications of HH.
The ratio of male to female was 8:7 in the group of cerebrovascular complications of HH, and mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 167.34 mm Hg and 112.56 mm Hg, respectively. In the NHH group, the mean SBP was 165.89 mm Hg, and the mean DBP was 113.47 mm Hg. The blood pressure of the HC group was in the normal range. The Ang II content was the highest in the group with cerebrovascular complications of HH, followed by the group with NHH, and the lowest in the HC group.
Pyrosequencing chart of patients with cerebrovascular complications of HH showed that the content of deoxyphosphate ribose G was the highest, while the content of A was the highest in NHH patients. Moreover, the serum adiponectin level of patients with HH and NHH was superior to that of the HC group, and the adiponectin level between the former two groups and the HC group differed considerably. Ang II levels were high in patients with cerebrovascular complications of HH and were positively correlated with adiponectin levels. The incidence of cerebrovascular complications of HH may be related to Ang II levels in patients.
本研究旨在探讨H型高血压（HH）脑血管并发症患者血管紧张素II（Ang II）基因与血清脂联素表达之间的相关性及其机制。
选取2022年1月至2023年6月在天津市第四中心医院门诊就诊的50例患者，根据血压及基本信息分为三组，即HH脑血管并发症组、非H型高血压（NHH）组和健康对照组（HC）。采集外周血样本；一份样本用于检测Ang II基因及Ang II的甲基化，另一份样本用于测定血清脂联素水平，以分析HH脑血管并发症患者血清脂联素水平与Ang II之间的关系。
HH脑血管并发症组男女比例为8:7，平均收缩压（SBP）和舒张压（DBP）分别为167.34 mmHg和112.56 mmHg。NHH组平均SBP为165.89 mmHg，平均DBP为113.47 mmHg。HC组血压在正常范围内。HH脑血管并发症组Ang II含量最高，其次是NHH组，HC组最低。
HH脑血管并发症患者的焦磷酸测序图显示脱氧磷酸核糖G含量最高，而NHH患者中A含量最高。此外，HH和NHH患者的血清脂联素水平均高于HC组，且前两组与HC组之间的脂联素水平差异显著。HH脑血管并发症患者Ang II水平较高，且与脂联素水平呈正相关。HH脑血管并发症的发生率可能与患者的Ang II水平有关。
