糖尿病管理与治疗（DIAMANT）队列研究。

The DIAbetes MANagement and Treatment (DIAMANT) Cohort.

作者信息

Overbeek Jetty A, Swart Karin M A, van der Pal Emma Y M, Blom Marieke T, Beulens Joline W J, Nijpels Giel, Elders Petra J M, Herings Ron M C

机构信息

Department Research, PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands.

Department of General Practice, Amsterdam UMC - Location Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

出版信息

Clin Epidemiol. 2022 Dec 5;14:1453-1462. doi: 10.2147/CLEP.S381728. eCollection 2022.

DOI:10.2147/CLEP.S381728

PMID:36506003

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9733447/

Abstract

INTRODUCTION

The increasing number of people with diabetes and the unclear long-term safety and effectiveness of newer and older blood-glucose-lowering treatments emphasize the need for more pharmaco-epidemiological studies in this field. A prospective, regularly updated cohort of people with diabetes would provide quick and up-to-date information regarding prevalence, treatment, safety and effectiveness. The current aim was to describe the design of the DIAbetes MANagement and Treatment (DIAMANT) cohort.

METHODS

The DIAMANT cohort is a population-based, dynamic, prospective cohort of persons with diabetes. It contains real-world data (RWD) from general practitioners (GP), including diagnoses, symptoms, examinations, communication to/from specialists and medication. Diabetes is defined as a recorded diabetes diagnosis or a prescription of drugs used in diabetes. The cohort is part of the national infrastructure of "Stichting Informatievoorziening voor Zorg en Onderzoek" (STIZON) and is linked to other data sources.

RESULTS

Currently, the cohort enables access to information of 89,883 patients in 2004 to 344,914 in 2020 (6% T1D, 84% T2D and 10% unclassified type of diabetes), with 193,931 participants still registered as being present in the GP practice (active) in 2020. The frequency of follow-up of persons with diabetes is practice dependent. The Dutch guidelines advise 2-4 contacts per year with a more extensive yearly check-up. The DIAMANT cohort is updated several times a year. Anonymised data from the DIAMANT cohort are available to researchers.

DISCUSSION

The DIAMANT cohort provides the opportunity to gain RWD insights into the treatment and outcomes among people with diabetes in daily general practice. The data can be enriched by established linkages to other data sources (eg, hospital data, the Perinatal Registry, the Cancer Registry). The DIAMANT cohort serves as a start of a national infrastructure to study, manage and provide personalised care in order to ultimately improve care and outcomes for people with diabetes.

摘要

引言

糖尿病患者人数不断增加，且新型和传统降糖治疗的长期安全性及有效性尚不明确，这凸显了在该领域开展更多药物流行病学研究的必要性。一个前瞻性、定期更新的糖尿病患者队列将能提供有关患病率、治疗、安全性和有效性的快速且最新的信息。当前的目标是描述糖尿病管理与治疗（DIAMANT）队列的设计。

方法

DIAMANT队列是一个基于人群的、动态的、前瞻性糖尿病患者队列。它包含来自全科医生（GP）的真实世界数据（RWD），包括诊断、症状、检查、与专科医生的沟通及用药情况。糖尿病定义为有记录的糖尿病诊断或糖尿病用药处方。该队列是“Stichting Informatievoorziening voor Zorg en Onderzoek”（STIZON）国家基础设施的一部分，并与其他数据源相链接。

结果

目前，该队列可获取2004年89,883名患者至2020年344,914名患者的信息（1型糖尿病占6%，2型糖尿病占84%，未分类糖尿病类型占10%），2020年仍有193,931名参与者在全科医生诊所登记在册（活跃）。糖尿病患者的随访频率取决于诊所。荷兰指南建议每年进行2 - 4次接触以及更全面的年度检查。DIAMANT队列每年更新数次。研究人员可获取DIAMANT队列的匿名数据。

讨论

DIAMANT队列提供了一个机会，可在日常全科医疗实践中获取有关糖尿病患者治疗及结局的真实世界数据见解。通过与其他数据源（如医院数据、围产期登记处、癌症登记处）建立既定的联系，数据可得到丰富。DIAMANT队列作为国家基础设施的开端，用于研究、管理和提供个性化护理，以最终改善糖尿病患者的护理及结局。