Lavigne Katie M, Kanagasabai Kesavi, Palaniyappan Lena
Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Montreal Neurological Institute-Hospital, McGill University, Montreal, QC, Canada.
Front Psychiatry. 2022 Nov 24;13:994372. doi: 10.3389/fpsyt.2022.994372. eCollection 2022.
Schizophrenia and related psychoses are complex neuropsychiatric diseases representing dysconnectivity across multiple scales, through the micro (cellular), meso (brain network), manifest (behavioral), and social (interpersonal) levels. human neuroimaging, particularly at ultra-high field (UHF), offers unprecedented opportunity to examine multiscale dysconnectivity in psychosis. In this review, we provide an overview of the literature to date on UHF in psychosis, focusing on microscale findings from magnetic resonance spectroscopy (MRS), mesoscale studies on structural and functional magnetic resonance imaging (fMRI), and multiscale studies assessing multiple neuroimaging modalities and relating UHF findings to behavior. We highlight key insights and considerations from multiscale and longitudinal studies and provide recommendations for future research on UHF neuroimaging in psychosis.
精神分裂症及相关精神病性障碍是复杂的神经精神疾病，其特征是在微观（细胞）、中观（脑网络）、显观（行为）和社会（人际）等多个层面存在连接异常。人类神经影像学，尤其是超高场（UHF）神经影像学，为研究精神病性障碍中的多尺度连接异常提供了前所未有的机会。在本综述中，我们概述了迄今为止关于超高场在精神病性障碍研究中的文献，重点关注磁共振波谱（MRS）的微观层面研究结果、结构和功能磁共振成像（fMRI）的中观层面研究，以及评估多种神经影像学模式并将超高场研究结果与行为相关联的多尺度研究。我们强调了多尺度和纵向研究的关键见解及注意事项，并为未来关于超高场神经影像学在精神病性障碍中的研究提供建议。
