Godlewska Beata R, Clare Stuart, Cowen Philip J, Emir Uzay E
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom.
Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Front Psychiatry. 2017 Jul 11;8:123. doi: 10.3389/fpsyt.2017.00123. eCollection 2017.
The advantages of ultra-high-field (UHF ≥ 7T) MR have been demonstrated in a variety of MR acquisition modalities. Magnetic resonance spectroscopy (MRS) can particularly benefit from substantial gains in signal-to-noise ratio (SNR) and spectral resolution at UHF, enabling the quantification of numerous metabolites, including glutamate, glutamine, glutathione, and γ-aminobutyric acid that are relevant to psychiatric disorders. The aim of this review is to give an overview about the advantages and advances of UHF MRS and its application to psychiatric disorders. In order to provide a practical guide for potential applications of MRS at UHF, a literature review is given, surveying advantages and disadvantages of MRS at UHF. Key concepts, emerging technologies, practical considerations, and applications of UHF MRS are provided. Second, the strength of UHF MRS is demonstrated using some examples of its application in psychiatric disorders.
超高场（UHF≥7T）磁共振成像（MR）的优势已在多种MR采集模式中得到证实。磁共振波谱（MRS）尤其能从超高场下显著提高的信噪比（SNR）和光谱分辨率中受益，从而能够对多种与精神疾病相关的代谢物进行定量分析，包括谷氨酸、谷氨酰胺、谷胱甘肽和γ-氨基丁酸。本综述的目的是概述超高场MRS的优势和进展及其在精神疾病中的应用。为了为超高场MRS的潜在应用提供实用指南，本文进行了文献综述，探讨了超高场MRS的优缺点。文中提供了超高场MRS的关键概念、新兴技术、实际考量因素及应用。其次，通过一些超高场MRS在精神疾病中的应用实例展示了其优势。
