Ozer Cora Ayfer, Guven Suleyman, Sal Hidayet, Tosun Ilknur, Guvendag Guven Emine Seda
Department of Obstetrics and Gynecology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Department of Microbiology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.
J Obstet Gynaecol India. 2022 Dec;72(6):497-502. doi: 10.1007/s13224-022-01677-0. Epub 2022 Aug 19.
This study aimed to investigate the serum levels of mucoprotein 3 in hypertensive diseases of pregnancy.
In total, 60 consecutive women with gestational hypertensive diseases (gestational hypertension ( = 20), severe preeclampsia ( = 20), HELLP syndrome ( = 20)) and 20 pregnant women without any gestational hypertensive diseases were included for this prospective controlled study. Serum MUC3 protein levels were measured with commercially available ELISA kits.
Serum MUC3 protein level was the lowest in normal pregnant women (0.1047 ± 0.0295 ng/ml); while the severity of the disease increases, it significantly increased in severe preeclampsia (0.2700 ± 0.0199 ng/mL) and HELLP syndrome group (0.3494 ± 0.0455 ng/mL), but less in the gestational hypertension (0.2172 ± 0.0354 ng/mL) group. Mean serum MUC3 protein level differences were found the least in gestational hypertension (0.1125 ± 0.0107, < 0.001), the most in HELLP syndrome (-0.2546 ± 0.0107, < 0.001) compared with the pregnant control group.
The increase in serum MUC3 protein concentration in these women supported the argument that serum MUC3 protein may be used as a marker indicating the severity of the gestational hypertensive diseases.
本研究旨在调查妊娠高血压疾病患者血清中粘蛋白3的水平。
本前瞻性对照研究共纳入60例连续的妊娠高血压疾病患者（妊娠期高血压（n = 20）、重度子痫前期（n = 20）、HELLP综合征（n = 20））以及20例无任何妊娠高血压疾病的孕妇。使用市售ELISA试剂盒检测血清MUC3蛋白水平。
正常孕妇血清MUC3蛋白水平最低（0.1047±0.0295 ng/ml）；随着疾病严重程度增加，重度子痫前期组（0.2700±0.0199 ng/mL）和HELLP综合征组（0.3494±0.0455 ng/mL）显著升高，而妊娠期高血压组（0.2172±0.0354 ng/mL）升高较少。与妊娠对照组相比，妊娠期高血压组血清MUC3蛋白水平差异最小（0.1125±0.0107，<0.001），HELLP综合征组差异最大（-0.2546±0.0107，<0.001）。
这些女性血清MUC3蛋白浓度升高支持了血清MUC3蛋白可作为指示妊娠高血压疾病严重程度标志物的观点。
