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来自L.的食品酶植酸酶的安全性评估

Safety evaluation of the food enzyme phytepsin from L.

作者信息

Lambré Claude, Barat Baviera José Manuel, Bolognesi Claudia, Cocconcelli Pier Sandro, Crebelli Riccardo, Gott David Michael, Grob Konrad, Lampi Evgenia, Mengelers Marcel, Mortensen Alicja, Rivière Gilles, Steffensen Inger-Lise, Tlustos Christina, Van Loveren Henk, Vernis Laurence, Zorn Holger, Roos Yrjö, Andryszkiewicz Magdalena, Liu Yi, Chesson Andrew

出版信息

EFSA J. 2022 Dec 7;20(12):e07681. doi: 10.2903/j.efsa.2022.7681. eCollection 2022 Dec.

Abstract

The food enzyme phytepsin (EC 3.4.23.40) is extracted from the pistils of the cardoon L. by ABIASA. It is intended to be used in milk processing for cheese production. As no concerns arose from the source of the food enzyme, from its manufacture, and based on the history of safe use and consumption, the Panel considered that toxicological data and the estimation of dietary exposure were not required. The Panel considered that allergic reactions to this phytepsin cannot be excluded in individuals allergic to this plant. However, the likelihood of allergic reactions to the phytepsin from L. is expected not to exceed the likelihood of allergic reactions to cardoon. As the prevalence of allergic reactions to cardoon is low, also the likelihood of such reaction to occur to the food enzyme is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

摘要

食品酶植酸酶(EC 3.4.23.40)由ABIASA从刺菜蓟的雌蕊中提取。它拟用于奶酪生产的牛奶加工。由于该食品酶的来源、生产过程均未引发担忧,且基于其安全使用和消费历史,专家小组认为无需毒理学数据和膳食暴露评估。专家小组认为,对该植物过敏的个体不能排除对这种植酸酶产生过敏反应。然而,预计对刺菜蓟来源的植酸酶发生过敏反应的可能性不会超过对刺菜蓟过敏反应的可能性。由于对刺菜蓟过敏反应的发生率较低,因此该食品酶发生此类反应的可能性也较低。根据所提供的数据,专家小组得出结论,在预期使用条件下,这种食品酶不会引起安全问题。

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本文引用的文献

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Scientific Guidance for the submission of dossiers on Food Enzymes.食品酶制剂资料提交的科学指南。
EFSA J. 2021 Oct 21;19(10):e06851. doi: 10.2903/j.efsa.2021.6851. eCollection 2021 Oct.
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Systemic allergic dermatitis caused by sesquiterpene lactones.倍半萜内酯引起的全身性变应性皮炎。
Contact Dermatitis. 2017 Jan;76(1):1-10. doi: 10.1111/cod.12671. Epub 2016 Aug 29.
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Multiplicity of aspartic proteinases from Cynara cardunculus L.刺菜蓟天冬氨酸蛋白酶的多样性
Planta. 2009 Jul;230(2):429-39. doi: 10.1007/s00425-009-0948-9. Epub 2009 Jun 2.

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