Thoracic Medicine Department 1, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Province, Changsha, 410013, People's Republic of China.
Department of Clinical Spiritual Care, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Province, Tongzipo Rd 283#, Yuelu District, Changsha, 410013, People's Republic of China.
Sci Rep. 2022 Dec 12;12(1):21466. doi: 10.1038/s41598-022-25068-7.
This study aimed to investigate the effects of cognitive behavioral therapy (CBT) on anxiety and depression in cancer survivors. The PubMed, Embase, PsycINFO, and Cochrane Library databases were searched. Randomized controlled trials that evaluated the effects of CBT in cancer survivors were included. The standardized mean difference (SMD) was used as an effect size indicator. Fifteen studies were included. For the depression score, the pooled results of the random effects model were as follows: pre-treatment versus post-treatment, SMD (95% confidence interval [CI]) = 0.88 (0.46, 1.29), P < 0.001; pre-treatment versus 3-month follow-up, 0.83 (0.09, 1.76), P = 0.08; pre-treatment versus 6-month follow-up, 0.92 (0.27, 1.58), P = 0.006; and pre-treatment versus 12-month follow-up, 0.21 (- 0.28, 0.70), P = 0.40. For the anxiety score, the pooled results of the random effects model were as follows: pre-treatment versus post-treatment, 0.97 (0.58, 1.36), P < 0.001; pre-treatment versus 3-month follow-up, 1.45 (- 0.82, 3.72), P = 0.21; and pre-treatment versus 6-month follow-up, 1.00 (0.17, 1.83), P = 0.02). The pooled result of the fixed effects model for the comparison between pre-treatment and the 12-month follow-up was 0.10 (- 0.16, 0.35; P = 0.45). The subgroup analysis revealed that the geographical location, treatment time and treatment form were not sources of significant heterogeneity. CBT significantly improved the depression and anxiety scores of the cancer survivors; such improvement was maintained until the 6-month follow-up. These findings support recommendations for the use of CBT in survivors of cancer.
本研究旨在探讨认知行为疗法（CBT）对癌症幸存者焦虑和抑郁的影响。检索了 PubMed、Embase、PsycINFO 和 Cochrane Library 数据库。纳入评估 CBT 对癌症幸存者影响的随机对照试验。使用标准化均数差（SMD）作为效应量指标。纳入了 15 项研究。对于抑郁评分，随机效应模型的汇总结果如下：治疗前与治疗后，SMD（95%置信区间[CI]）= 0.88（0.46，1.29），P<0.001；治疗前与 3 个月随访，0.83（0.09，1.76），P=0.08；治疗前与 6 个月随访，0.92（0.27，1.58），P=0.006；治疗前与 12 个月随访，0.21（-0.28，0.70），P=0.40。对于焦虑评分，随机效应模型的汇总结果如下：治疗前与治疗后，0.97（0.58，1.36），P<0.001；治疗前与 3 个月随访，1.45（-0.82，3.72），P=0.21；治疗前与 6 个月随访，1.00（0.17，1.83），P=0.02）。固定效应模型治疗前与 12 个月随访比较的汇总结果为 0.10（-0.16，0.35；P=0.45）。亚组分析显示，地理位置、治疗时间和治疗形式不是异质性的来源。CBT 显著改善了癌症幸存者的抑郁和焦虑评分；这种改善持续到 6 个月随访。这些发现支持在癌症幸存者中使用 CBT 的建议。
