Nakamine H, Okamoto Y, Tsuda T, Shimizu E, Nishino E, Ohta K, Takenaka T, Maeda J
Department of Laboratory Medicine, Wakayama Medical School, Japan.
Cancer. 1987 Oct 15;60(8):1751-6. doi: 10.1002/1097-0142(19871015)60:8<1751::aid-cncr2820600813>3.0.co;2-g.
A case of Hodgkin's disease (HD) in a patient with long-standing hairy cell leukemia (HCL) is reported. The diagnosis of HCL was confirmed by clinical features (chronic illness with marked splenomegaly) and hematopathologic findings (increase of characteristic hairy cells with tartrate-resistant acid phosphatase activity in peripheral blood and bone marrow). Cervical lymphadenopathy first appeared 6 years after the diagnosis of HCL, and histologic features of the node were characteristic of HD. As it was possible that the neoplastic cells of both lesions might have originated from a single clone, their phenotypic features were defined. The hairy cells were found to bear surface immunoglobulin, receptors for complement components, leukocyte common antigen, and antigen defined by LN-1 monoclonal antibody, whereas lymph node lesion was characterized as HD because the Reed-Sternberg-like cells were positive for Leu M1 antigen, lysozyme, alpha-1-antitrypsin, and nonspecific cross-reacting antigen. Since there was no evidence indicating a common clonal origin, it is more likely to consider that both lesions are derived from different clones.
报告了1例患有长期毛细胞白血病（HCL）的霍奇金淋巴瘤（HD）患者。HCL的诊断通过临床特征（伴有明显脾肿大的慢性病）和血液病理学检查结果（外周血和骨髓中具有抗酒石酸酸性磷酸酶活性的特征性毛细胞增多）得以证实。颈部淋巴结病在HCL诊断6年后首次出现，淋巴结的组织学特征为HD所特有。由于两种病变的肿瘤细胞可能源自单一克隆，因此对其表型特征进行了界定。发现毛细胞表面带有免疫球蛋白、补体成分受体、白细胞共同抗原以及由LN-1单克隆抗体所定义的抗原，而淋巴结病变被表征为HD，因为里德-斯腾伯格样细胞对Leu M1抗原、溶菌酶、α1-抗胰蛋白酶和非特异性交叉反应抗原呈阳性。由于没有证据表明存在共同的克隆起源，因此更有可能认为这两种病变源自不同的克隆。
