Department of Radiology, University of Pittsburgh, Pittsburgh 15224, PA, USA.
Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao 48007, Spain.
Dev Cogn Neurosci. 2022 Dec;58:101179. doi: 10.1016/j.dcn.2022.101179. Epub 2022 Nov 24.
The ventral visual stream is shaped during development by innate proto-organization within the visual system, such as the strong input from the fovea to the fusiform face area. In adults, category-selective regions have distinct signatures of connectivity to brain regions beyond the visual system, likely reflecting cross-modal and motoric associations. We tested if this long-range connectivity is part of the innate proto-organization, or if it develops with postnatal experience, by using diffusion-weighted imaging to characterize the connectivity of anatomical correlates of category-selective regions in neonates (N = 445), 1-9 month old infants (N = 11), and adults (N = 14). Using the HCP data we identified face- and place- selective regions and a third intermediate region with a distinct profile of selectivity. Using linear classifiers, these regions were found to have distinctive connectivity at birth, to other regions in the visual system and to those outside of it. The results support an extended proto-organization that includes long-range connectivity that shapes, and is shaped by, experience-dependent development.
腹侧视觉流在发育过程中受到视觉系统内固有原组织的影响，例如来自中央凹的强烈输入到梭状回面孔区。在成年人中，类别选择性区域与视觉系统以外的大脑区域具有明显的连接特征，可能反映了跨模态和运动关联。我们通过使用扩散加权成像来研究这种长程连接是否是固有原组织的一部分，或者是否是在出生后经验中发展起来的，以表征新生儿（N=445）、1-9 个月大的婴儿（N=11）和成年人（N=14）中类别选择性区域的解剖学相关性的连接。使用 HCP 数据，我们确定了面孔和位置选择性区域，以及具有独特选择性特征的第三个中间区域。使用线性分类器，这些区域在出生时就具有独特的连接，与视觉系统内的其他区域以及视觉系统外的区域连接。结果支持了一种扩展的原组织，包括长程连接，这种连接塑造并受经验依赖性发育的影响。
