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索引入院胆囊切除术治疗胆绞痛可预防胆道并发症再入院的风险,应作为标准治疗。

Index Admission Cholecystectomy for Biliary Colic Precludes the Risk of Readmissions with Biliary Complications and should be Standard Treatment.

机构信息

Department of General and Upper GI Surgery, Ninewells Hospital, Dundee, United Kingdom.

出版信息

World J Surg. 2023 Mar;47(3):658-665. doi: 10.1007/s00268-022-06847-9. Epub 2022 Dec 16.

Abstract

BACKGROUND

Emergency biliary colic admissions can be managed with an index or elective laparoscopic cholecystectomy (LC). Opting to perform an elective LC may have significant repercussions such as the risk of readmissions before operation with further attacks or with biliary complications (e.g. cholecystitis, pancreatitis, choledocholithiasis). The risk of readmission and biliary complications in patients admitted with biliary colic but scheduled for elective surgery has never been investigated. The secondary aim was to compare rates of peri-operative morbidity between the index admission, elective and readmission LC cohorts.

METHOD

All patients admitted with a diagnosis of biliary colic over a 5-year period and proceeding to LC were included in the study (n = 441). The risk of being readmitted and suffering further morbidity whilst awaiting elective LC was investigated. Peri-operative morbidity was compared between the index admission, elective and readmitted LC groups using univariate and multivariate analysis.

RESULTS

Following a biliary colic admission, the risk of readmission whilst awaiting elective LC is significant (2 months-25%; 10 months-48%). In this group, the risks of subsequent biliary complications (18.0%) and the requirement for ERCP (6.5%) were significant. Patients who are readmitted before LC, suffer a more complicated peri-operative course (longer total length of stay, higher post-operative complications, imaging and readmission).

DISCUSSION

Index admission LC for biliary colic avoids the significant risk of readmission and biliary complications before surgery and should be the gold standard. Readmitted patients are likely to have higher rates of peri-operative adverse outcomes. Patients should be counselled about these risks.

摘要

背景

急诊胆绞痛患者可通过指数或择期腹腔镜胆囊切除术(LC)进行治疗。选择进行择期 LC 可能会产生重大影响,例如在手术前因再次发作或出现胆道并发症(如胆囊炎、胰腺炎、胆总管结石)而需要再次入院。因胆绞痛入院但计划接受择期手术的患者在入院后发生再入院和胆道并发症的风险尚未得到调查。次要目标是比较指数入院、择期和再入院 LC 队列之间围手术期发病率。

方法

在 5 年期间,所有因胆绞痛入院并接受 LC 治疗的患者均被纳入研究(n=441)。研究了在等待择期 LC 期间再次入院和发生进一步并发症的风险。使用单变量和多变量分析比较指数入院、择期和再入院 LC 组之间的围手术期发病率。

结果

在胆绞痛入院后,等待择期 LC 时再次入院的风险显著(2 个月-25%;10 个月-48%)。在该组中,随后发生胆道并发症(18.0%)和需要 ERCP(6.5%)的风险显著增加。在 LC 前再次入院的患者,围手术期过程更为复杂(总住院时间更长、术后并发症、影像学检查和再入院的发生率更高)。

讨论

对胆绞痛进行指数入院 LC 可避免手术前再次入院和胆道并发症的重大风险,应作为金标准。再次入院的患者可能有更高的围手术期不良结局发生率。应向患者告知这些风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/353d/9895019/997dc9ee8c29/268_2022_6847_Fig1_HTML.jpg

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