Hsu Simon, Criqui Michael H, Ginsberg Charles, Hoofnagle Andrew N, Ix Joachim H, McClelland Robyn L, Michos Erin D, Shea Steven J, Siscovick David, Zelnick Leila R, Kestenbaum Bryan R, de Boer Ian H
Division of Nephrology and Kidney Research Institute, Department of Medicine University of Washington Seattle WA USA.
Division of Preventive Medicine, Department of Family Medicine University of California, San Diego La Jolla CA USA.
JBMR Plus. 2022 Nov 11;6(12):e10697. doi: 10.1002/jbm4.10697. eCollection 2022 Dec.
Studies on associations between biomarkers of vitamin D metabolism and fracture risk have focused predominantly on White or elderly populations and may not be generalizable to relatively healthy multiethnic populations. We tested associations of total 25-hydroxyvitamin D (25[OH]D), the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (vitamin D metabolite ratio, VDMR), parathyroid hormone (PTH), and fibroblast growth factor-23 (FGF-23) concentrations measured in serum with risk of hip and vertebral fractures in the Multi-Ethnic Study of Atherosclerosis (MESA). Serum 25-hydroxyvitamin D and D and 24,25-dihydroxyvitamin D were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The study cohort of 6466 participants was without clinically apparent cardiovascular disease and was 39% White, 27% Black, 22% Hispanic, and 12% Chinese. The mean age was 62 years, and 53% were female. There were 128 hip and vertebral fractures over a mean follow-up of 14.2 years. 25(OH)D, the VDMR, PTH, and FGF-23 were not significantly associated with fracture risk after adjustment for demographics, diabetes, smoking, systolic blood pressure, body mass index, medication use, albuminuria, and estimated glomerular filtration rate. Principal component analysis did not suggest differences in linear combinations of 25(OH)D, the VDMR, PTH, and FGF-23 between participants who experienced fractures and those who did not. We did not observe significant interaction between race and ethnicity and any biomarker of vitamin D metabolism on fracture risk. In conclusion, none of the four serum biomarkers of vitamin D metabolism investigated showed a significant association with fracture risk in relatively healthy multiethnic populations. © 2022 The Authors. published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
关于维生素D代谢生物标志物与骨折风险之间关联的研究主要集中在白人或老年人群体，可能不适用于相对健康的多民族人群。我们在动脉粥样硬化多民族研究（MESA）中测试了血清中总25-羟基维生素D（25[OH]D）、24,25-二羟基维生素D与25-羟基维生素D的比值（维生素D代谢物比值，VDMR）、甲状旁腺激素（PTH）和成纤维细胞生长因子-23（FGF-23）浓度与髋部和椎体骨折风险的关联。血清25-羟基维生素D和24,25-二羟基维生素D通过液相色谱-串联质谱法（LC-MS/MS）测定。6466名参与者的研究队列无明显临床心血管疾病，其中39%为白人，27%为黑人，22%为西班牙裔，12%为中国人。平均年龄为62岁，53%为女性。在平均14.2年的随访期间，有128例髋部和椎体骨折。在调整了人口统计学、糖尿病、吸烟、收缩压、体重指数、药物使用、白蛋白尿和估计肾小球滤过率后，25(OH)D、VDMR、PTH和FGF-23与骨折风险无显著关联。主成分分析未提示骨折参与者与未骨折参与者之间25(OH)D、VDMR、PTH和FGF-23的线性组合存在差异。我们未观察到种族和民族与任何维生素D代谢生物标志物在骨折风险上的显著相互作用。总之，在所研究的四种维生素D代谢血清生物标志物中，没有一种在相对健康的多民族人群中与骨折风险显示出显著关联。© 2022作者。由Wiley Periodicals LLC代表美国骨与矿物质研究学会出版。
